Article: article from journal or magazin.
Surface modification of biomaterials for conjugation with human fetal osteoblasts.
Publication types: Journal Article
Surface functionalization of hydroxyapatite (HA) and beta-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.
Biocompatible Materials/chemistry, Biocompatible Materials/metabolism, Calcium Phosphates/chemistry, Calcium Phosphates/metabolism, Cell Adhesion, Cell Proliferation, Cells, Cultured, Ceramics/chemistry, Ceramics/metabolism, Click Chemistry, Durapatite/chemistry, Durapatite/metabolism, Fetus/cytology, Fetus/metabolism, Humans, Materials Testing, Molecular Structure, Osteoblasts/cytology, Osteoblasts/metabolism, Surface Properties
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