Plasminogen activator inhibitor 1: a new prognostic marker in septic shock

Details

Serval ID
serval:BIB_E1D7107B5665
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plasminogen activator inhibitor 1: a new prognostic marker in septic shock
Journal
Thrombosis and Haemostasis
Author(s)
Pralong  G., Calandra  T., Glauser  M. P., Schellekens  J., Verhoef  J., Bachmann  F., Kruithof  E. K.
ISSN
0340-6245 (Print)
Publication state
Published
Issued date
06/1989
Volume
61
Number
3
Pages
459-62
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't --- Old month value: Jun 30
Abstract
The prognostic value of plasminogen activator inhibitor type 1 (PAI-1) in septic shock was investigated in 52 patients with septic shock. The patients had significantly elevated serum PAI-1 levels with respect to the control group (p = 0.002). In patients not having a rapidly fatal underlying disease, PAI-1 was significantly higher in patients dying within a week after onset of shock than in survivors (median PAI-1: 900 and 307 ng/ml, respectively; p = 0.001). The analysis of the distribution of PAI-1 levels permitted retrospectively to determine a threshold level of PAI-1 which had prognostic significance. Mortality was 71% in patients with serum PAI-1 above 550 ng/ml, whereas only two patients (6%) having a PAI-1 below 550 ng/ml died within a week. Thus, in patients with septic shock, PAI-1 appears to have a strong predictive value as to mortality. This early marker may help the clinician in identifying a subgroup of patients particularly at risk.
Keywords
Adolescent Adult Aged Biological Markers/blood Child Double-Blind Method Female Humans Male Middle Aged Plasminogen Activators/*antagonists & inhibitors Plasminogen Inactivators/*blood Prognosis Randomized Controlled Trials Shock, Septic/*blood/mortality
Pubmed
Web of science
Create date
25/01/2008 13:28
Last modification date
20/08/2019 16:05
Usage data