Hipertensión y edema pulmonar de altura. Rol de la disfunción endotelial y de la programación fetal [Pulmonary hypertension and lung edema at high altitude. Role of endothelial dysfunction and fetal programming].

Details

Serval ID
serval:BIB_E1D4D01048FB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Hipertensión y edema pulmonar de altura. Rol de la disfunción endotelial y de la programación fetal [Pulmonary hypertension and lung edema at high altitude. Role of endothelial dysfunction and fetal programming].
Journal
Medicina
Author(s)
Schwab M., Allemann Y., Rexhaj E., Rimoldi S.F., Sartori C., Scherrer U.
ISSN
0025-7680 (Print)
ISSN-L
0025-7680
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
72
Number
2
Pages
150-157
Language
spanish
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Abstract
High altitude constitutes an exciting natural laboratory for medical research. While initially, the aim of high-altitude research was to understand the adaptation of the organism to hypoxia and find treatments for altitude-related diseases, over the past decade or so, the scope of this research has broadened considerably. Two important observations led to the foundation for the broadening of the scientific scope of high-altitude research. First, high-altitude pulmonary edema (HAPE) represents a unique model which allows studying fundamental mechanisms of pulmonary hypertension and lung edema in humans. Secondly, the ambient hypoxia associated with high-altitude exposure facilitates the detection of pulmonary and systemic vascular dysfunction at an early stage. Here, we review studies that, by capitalizing on these observations, have led to the description of novel mechanisms underpinning lung edema and pulmonary hypertension and to the first direct demonstration of fetal programming of vascular dysfunction in humans.
Pubmed
Web of science
Create date
22/01/2013 16:26
Last modification date
20/08/2019 17:05
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