The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole.

Détails

ID Serval
serval:BIB_E1B04AC40760
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole.
Périodique
Cell
Auteur(s)
Shulman J.M., Benton R., St Johnston D.
ISSN
0092-8674[print], 0092-8674[linking]
Statut éditorial
Publié
Date de publication
05/2000
Volume
101
Numéro
4
Pages
377-388
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
In C. elegans, the PAR-1 kinase is localized to the posterior of the zygote and is required for anterior-posterior axis formation. Here, we report that a Drosophila PAR-1 homolog localizes to the posterior of the oocyte with oskar mRNA. Furthermore, par-1 mutants show a novel polarity phenotype in which bicoid mRNA accumulates normally at the anterior, but oskar mRNA is redirected to the center of the oocyte, resulting in embryonic patterning defects. These phenotypes arise from a disorganization of the oocyte microtubule cytoskeleton, consistent with reports that mammalian PAR-1 homologs regulate microtubule dynamics. Thus, Drosophila PAR-1 may remodel the oocyte microtubule network to define the posterior as the site for oskar localization. These results identify a molecular parallel between anterior-posterior polarization in Drosophila and C. elegans.
Mots-clé
Animals, Caenorhabditis elegans/genetics, Caenorhabditis elegans Proteins, Cytoskeleton/metabolism, Drosophila/genetics, Drosophila/metabolism, Drosophila Proteins, Female, Gene Expression Regulation, Helminth Proteins/genetics, Helminth Proteins/metabolism, Insect Proteins/genetics, Insect Proteins/metabolism, Molecular Sequence Data, Oocytes/metabolism, Oocytes/ultrastructure, Protein-Serine-Threonine Kinases/genetics, Protein-Serine-Threonine Kinases/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
18/03/2008 10:36
Dernière modification de la notice
20/08/2019 16:05
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