Article: article from journal or magazin.
Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway1
PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, P.H.S
Cell cycle regulation is critical for maintenance of genome integrity. A prominent factor that guarantees genomic stability of cells is p53 (ref. 1). The P53 gene encodes a transcription factor that has a role as a tumour suppressor. Identification of p53-target genes should provide greater insight into the molecular mechanisms that mediate the tumour suppressor activities of p53. The rodent Pc3/Tis21 gene was initially described as an immediate early gene induced by tumour promoters and growth factors in PC12 and Swiss 3T3 cells. It is expressed in a variety of cell and tissue types and encodes a remarkably labile protein. Pc3/Tis21 has a strong sequence similarity to the human antiproliferative BTG1 gene cloned from a chromosomal translocation of a B-cell chronic lymphocytic leukaemia. This similarity led us to speculate that BTG1 and the putative human homologue of Pc3/Tis21 (named BTG2) were members of a new family of genes involved in growth control and/or differentiation. This hypothesis was recently strengthened by the identification of a new antiproliferative protein, named TOB, which shares sequence similarity with BTG1 and PC3/TIS21 (ref. 7). Here, we cloned and localized the human BTG2 gene. We show that BTG2 expression is induced through a p53-dependent mechanism and that BTG2 function may be relevant to cell cycle control and cellular response to DNA damage
3T3 Cells/Amino Acid Sequence/Animals/Cell Cycle/genetics/physiology/Cell Division/Cell Line/Chromosome Mapping/Chromosomes,Human,Pair 1/Cloning,Molecular/DNA Damage/Gene Expression Regulation/Genes,Tumor Suppressor/Humans/Hybrid Cells/Immediate-Early Proteins/Mice/Molecular Sequence Data/Neoplasm Proteins/Proteins/Sequence Homology,Amino Acid/Tumor Suppressor Protein p53
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