Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.

Details

Serval ID
serval:BIB_E17C3B93B35B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development.
Journal
Molecular and Cellular Biology
Author(s)
Di-Poï N., Ng C.Y., Tan N.S., Yang Z., Hemmings B.A., Desvergne B., Michalik L., Wahli W.
ISSN
0270-7306[print], 0270-7306[linking]
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
25
Number
5
Pages
1696-1712
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Hair follicle morphogenesis depends on a delicate balance between cell proliferation and apoptosis, which involves epithelium-mesenchyme interactions. We show that peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) and Akt1 are highly expressed in follicular keratinocytes throughout hair follicle development. Interestingly, PPARbeta/delta- and Akt1-deficient mice exhibit similar retardation of postnatal hair follicle morphogenesis, particularly at the hair peg stage, revealing a new important function for both factors in the growth of early hair follicles. We demonstrate that a time-regulated activation of the PPARbeta/delta protein in follicular keratinocytes involves the up-regulation of the cyclooxygenase 2 enzyme by a mesenchymal paracrine factor, the hepatocyte growth factor. Subsequent PPARbeta/delta-mediated temporal activation of the antiapoptotic Akt1 pathway in vivo protects keratinocytes from hair pegs against apoptosis, which is required for normal hair follicle development. Together, these results demonstrate that epithelium-mesenchyme interactions in the skin regulate the activity of PPARbeta/delta during hair follicle development via the control of ligand production and provide important new insights into the molecular biology of hair growth.
Keywords
Animals, Apoptosis/physiology, Cyclooxygenase 2, Epithelium/chemistry, Epithelium/growth &amp, development, Hair Follicle/chemistry, Hair Follicle/cytology, Hepatocyte Growth Factor/genetics, Hepatocyte Growth Factor/physiology, Intercellular Signaling Peptides and Proteins/physiology, Keratinocytes/chemistry, Keratinocytes/cytology, Mesoderm/physiology, Mice, Mice, Knockout, Models, Biological, Morphogenesis/genetics, Morphogenesis/physiology, PPAR delta/genetics, PPAR delta/metabolism, PPAR-beta/genetics, PPAR-beta/metabolism, Paracrine Communication/physiology, Phosphorylation, Prostaglandin-Endoperoxide Synthases/physiology, Protein-Serine-Threonine Kinases/analysis, Protein-Serine-Threonine Kinases/genetics, Proto-Oncogene Proteins/analysis, Proto-Oncogene Proteins/genetics, Proto-Oncogene Proteins c-akt
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:26
Last modification date
20/08/2019 16:05
Usage data