Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation.

Details

Serval ID
serval:BIB_E154CCF2414B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Anything but Ordinary - Emerging Splicing Mechanisms in Eukaryotic Gene Regulation.
Journal
Trends in genetics
Author(s)
Gehring N.H., Roignant J.Y.
ISSN
0168-9525 (Print)
ISSN-L
0168-9525
Publication state
Published
Issued date
04/2021
Peer-reviewed
Oui
Volume
37
Number
4
Pages
355-372
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Splicing of precursor mRNAs (pre-mRNA) is an important step during eukaryotic gene expression. The identification of the actual splice sites and the proper removal of introns are essential for the production of the desired mRNA isoforms and their encoded proteins. While the basic mechanisms of splicing regulation are well understood, recent work has uncovered a growing number of noncanonical splicing mechanisms that play key roles in the regulation of gene expression. In this review, we summarize the current principles of splicing regulation, including the impact of cis and trans regulatory elements, as well as the influence of chromatin structure, transcription, and RNA modifications. We further discuss the recent development of emerging splicing mechanisms, such as recursive and back splicing, and their impact on gene expression.
Keywords
Genetics, RNA modifications, RNA-binding protein, circular RNA, cotranscriptional splicing, pre-mRNA splicing, recursive splicing
Pubmed
Web of science
Open Access
Yes
Create date
18/11/2020 16:46
Last modification date
01/05/2021 5:32
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