Frequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species.
Details
Serval ID
serval:BIB_E14F344895B2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Frequency and impact on renal transplant outcomes of urinary tract infections due to extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species.
Journal
Frontiers in medicine
Working group(s)
Swiss Transplant Cohort Study
Contributor(s)
Amico P., Aubert J.D., Bachofner A., Banz V., Beckmann S., Beldi G., Berger C., Berishvili E., Berzigotti A., Bochud P.Y., Branca S., Bucher H., Cairoli A., Catana E., Chalandon Y., De Geest S., De Seigneux S., Dickenmann M., Lynn Dreifuss J., Duchosal M., Fehr T., Ferrari-Lacraz S., Frossard J., Garzoni C., Golshayan D., Goossens N., Haidar F., Halter J., Heim D., Hess C., Hillinger S., Hirsch H., Hirt P., Hoessly L., Hofbauer G., Huynh-Do U., Immer F., Koller M., Kremer A., Kuhn C., Laesser B., Lamoth F., Lehmann R., Leichtle A., Manuel O., Marti H.P., Martinelli M., McLin V., Mellac K., Merçay A., Mettler K., Müller N., Müller-Arndt U., Müllhaupt B., Nägeli M., Oldani G., Pascual M., Passweg J., Pazeller R., Posfay-Barbe K., Reineke D., Rick J., Rosselet A., Rossi S., Rössler X., Rothlin S., Ruschitzka F., Schachtner T., Schaub S., Scherrer A., Schneidawind D., Schnyder A., Schuurmans M., Schwab S., Sengstag T., Simonetta F., Steiger J., Stirniman G., Stürzinger U., Van Delden C., Venetz J.P., Villard J., Vionnet J., Wick M., Wilhlem M., Yerly P.
ISSN
2296-858X (Print)
ISSN-L
2296-858X
Publication state
Published
Issued date
2024
Peer-reviewed
Oui
Editor
Amico P Aubert J. D. Bachofner A. Banz V. Beckmann S. Beldi G. Berger C. Berishvili E. Berzigotti A. Bochud P. Y. Branca S. Bucher H. Cairoli A. Catana E. Chalandon Y. De Geest S. De Seigneux S. Dickenmann M. Lynn Dreifuss J. Duchosal M. Fehr T. Ferrari-Lacraz S. Frossard J. Garzoni C. Golshayan D. Goossens N. Haidar F. Halter J. Heim D. Hess C. Hillinger S. Hirsch H. Hirt P. Hoessly L. Hofbauer G. Huynh-Do U. Immer F. Koller M. Kremer A. Kuhn C. Laesser B. Lamoth F. Lehmann R. Leichtle A. Manuel O. Marti H. P. Martinelli M. McLin V. Mellac K. Mercay A. Mettler K. Muller N. Muller-Arndt U. Mullhaupt B. Nageli M. Oldani G. Pascual M. Passweg J. Pazeller R. Posfay-Barbe K. Reineke D. Rick J. Rosselet A. Rossi S. Rossler Rothlin S. Ruschitzka F. Schachtner T. Schaub S. Scherrer A. Schneidawind D. Schnyder A. Schuurmans M. Schwab S. Sengstag T. Simonetta F. Steiger J. Stirniman G. Sturzinger U. Van Delden C. Venetz J. P. Villard J. Vionnet J. Wick M. Wilhlem M. Yerly P.
Volume
11
Pages
1329778
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Enterobacterales are often responsible for urinary tract infection (UTI) in kidney transplant recipients. Among these, Escherichia coli or Klebsiella species producing extended-spectrum beta-lactamase (ESBL) are emerging. However, there are only scarce data on frequency and impact of ESBL-UTI on transplant outcomes.
We investigated frequency and impact of first-year UTI events with ESBL Escherichia coli and/or Klebsiella species in a prospective multicenter cohort consisting of 1,482 kidney transplants performed between 2012 and 2017, focusing only on 389 kidney transplants having at least one UTI with Escherichia coli and/or Klebsiella species. The cohort had a median follow-up of four years.
In total, 139/825 (17%) first-year UTI events in 69/389 (18%) transplant recipients were caused by ESBL-producing strains. Both UTI phenotypes and proportion among all UTI events over time were not different compared with UTI caused by non-ESBL-producing strains. However, hospitalizations in UTI with ESBL-producing strains were more often observed (39% versus 26%, p = 0.04). Transplant recipients with first-year UTI events with an ESBL-producing strain had more frequently recurrent UTI (33% versus 18%, p = 0.02) but there was no significant difference in one-year kidney function as well as longer-term graft and patient survival between patients with and without ESBL-UTI.
First-year UTI events with ESBL-producing Escherichia coli and/or Klebsiella species are associated with a higher need for hospitalization but do neither impact allograft function nor allograft and patient survival.
We investigated frequency and impact of first-year UTI events with ESBL Escherichia coli and/or Klebsiella species in a prospective multicenter cohort consisting of 1,482 kidney transplants performed between 2012 and 2017, focusing only on 389 kidney transplants having at least one UTI with Escherichia coli and/or Klebsiella species. The cohort had a median follow-up of four years.
In total, 139/825 (17%) first-year UTI events in 69/389 (18%) transplant recipients were caused by ESBL-producing strains. Both UTI phenotypes and proportion among all UTI events over time were not different compared with UTI caused by non-ESBL-producing strains. However, hospitalizations in UTI with ESBL-producing strains were more often observed (39% versus 26%, p = 0.04). Transplant recipients with first-year UTI events with an ESBL-producing strain had more frequently recurrent UTI (33% versus 18%, p = 0.02) but there was no significant difference in one-year kidney function as well as longer-term graft and patient survival between patients with and without ESBL-UTI.
First-year UTI events with ESBL-producing Escherichia coli and/or Klebsiella species are associated with a higher need for hospitalization but do neither impact allograft function nor allograft and patient survival.
Keywords
E. coli, ESBL − extended-spectrum beta-lactamase, Enterobacterales, Klebsiella, graft survival, kidney transplantation, urinary tract infection
Pubmed
Web of science
Open Access
Yes
Create date
04/03/2024 16:12
Last modification date
06/11/2024 7:11
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