Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_E1256C4C82EF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART.
Journal
Nature communications
Author(s)
Bachmann N., von Siebenthal C., Vongrad V., Turk T., Neumann K., Beerenwinkel N., Bogojeska J., Fellay J., Roth V., Kok Y.L., Thorball C.W., Borghesi A., Parbhoo S., Wieser M., Böni J., Perreau M., Klimkait T., Yerly S., Battegay M., Rauch A., Hoffmann M., Bernasconi E., Cavassini M., Kouyos R.D., Günthard H.F., Metzner K.J.
Working group(s)
Swiss HIV Cohort Study
Contributor(s)
Anagnostopoulos A., Battegay M., Bernasconi E., Böni J., Braun D.L., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Günthard H.F., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Huber M., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R.D., Kovari H., Ledergerber B., Martinetti G., Tejada B.M., Marzolini C., Metzner K.J., Müller N., Nicca D., Paioni P., Pantaleo G., Perreau M., Rauch A., Rudin C., Scherrer A.U., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Vernazza P., Wandeler G., Weber R., Yerly S.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
19/07/2019
Peer-reviewed
Oui
Volume
10
Number
1
Pages
3193
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The HIV-1 reservoir is the major hurdle to a cure. We here evaluate viral and host characteristics associated with reservoir size and long-term dynamics in 1,057 individuals on suppressive antiretroviral therapy for a median of 5.4 years. At the population level, the reservoir decreases with diminishing differences over time, but increases in 26.6% of individuals. Viral blips and low-level viremia are significantly associated with slower reservoir decay. Initiation of ART within the first year of infection, pretreatment viral load, and ethnicity affect reservoir size, but less so long-term dynamics. Viral blips and low-level viremia are thus relevant for reservoir and cure studies.
URN
urn:nbn:ch:serval-BIB_E1256C4C82EF0
OAI-PMH
oai:serval.unil.ch:BIB_E1256C4C82EF
DOI
10.1038/s41467-019-10884-9
Pubmed
31324762
Web of science
000476471300002
Open Access
Yes
Create date
04/08/2019 14:55
Last modification date
30/04/2021 6:15
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