Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Integration of the metabolic data of positron emission tomography in the dosimetry planning of radiosurgery with the gamma knife: early experience with brain tumors. Technical note.
Journal of Neurosurgery
Publication types: Case Reports ; Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
The purpose of this study was to assess the use of positron emission tomography (PET) as a stereotactic planning modality for gamma knife radiosurgery (GKS). The authors developed and validated a technique for fiducial marker imaging, importation, and handling of PET data for integration into GammaPlan planning software. The clinical feasibility in applying this approach to a selected group of patients presenting with recurrent glial tumors or metastases was evaluated. Positron emission tomography data can be integrated into GammaPlan, allowing a high spatial accuracy, as validated using a phantom. Positron emission tomography data were successfully combined with magnetic resonance (MR) images to define the target volume for the radiosurgical treatment of patients with recurrent glioma or metastasis. This approach may contribute to optimizing target selection for infiltrating or ill-defined brain lesions. Because PET is also useful for the pretreatment and follow-up evaluation, the use of stereotactic PET in these patients can enable an accurate comparison of PET-based metabolic data with MR-based anatomical data. This could give a better understanding of the metabolic changes following radiosurgery. The ability to use PET data in GKS represents a crucial step toward further developments in radiosurgery, as this approach provides additional information that may open new perspectives for the optimization of the treatment of brain tumors.
Adolescent, Brain Neoplasms/physiopathology, Brain Neoplasms/radionuclide imaging, Energy Metabolism/physiology, Female, Glioma/physiopathology, Glioma/radionuclide imaging, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging/instrumentation, Male, Middle Aged, Neoplasm Recurrence, Local/physiopathology, Neoplasm Recurrence, Local/radionuclide imaging, Radiosurgery/instrumentation, Reoperation, Reproducibility of Results, Software, Tomography, Emission-Computed/instrumentation
Web of science
Last modification date