Chloride transport in the proximal renal tubule

Détails

ID Serval
serval:BIB_E0ADD8AF7D43
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Chloride transport in the proximal renal tubule
Périodique
Annual Review of Physiology
Auteur(s)
Schild  L., Giebisch  G., Green  R.
ISSN
0066-4278 (Print)
Statut éditorial
Publié
Date de publication
1988
Volume
50
Pages
97-110
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Résumé
Our knowledge of chloride transport along the nephron has greatly expanded. Whereas for a long time it was assumed that chloride ions were reabsorbed entirely passively with sodium--the "mendicant" role of chloride, more recent studies suggest that several distinct reabsorptive transport mechanisms operate in parallel. Accordingly, a new model of proximal chloride transport has evolved that includes both active, transcellular as well as passive, intercellular transport pathways. Transcellular chloride reabsorption involves anion exchange mechanisms in both the luminal and peritubular cell membranes, processes that also depend on sodium, hydrogen, and bicarbonate ions. Chloride transport is thus intimately related to sodium and fluid transport as well as to cell acid-base metabolism. Unresolved problems concern the relative magnitude of transcellular and paracellular chloride transport and the details of luminal and basolateral chloride translocation steps.
Mots-clé
Animals Chlorides/*pharmacokinetics Humans Kidney Tubules, Proximal/*physiology
Pubmed
Web of science
Création de la notice
24/01/2008 13:56
Dernière modification de la notice
20/08/2019 17:04
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