Urease-based mucosal immunization against Helicobacter heilmannii infection induces corpus atrophy in mice

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Serval ID
serval:BIB_E084BE5A1C8C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Urease-based mucosal immunization against Helicobacter heilmannii infection induces corpus atrophy in mice
Journal
Infection and Immunity
Author(s)
Dieterich  C., Bouzourene  H., Blum  A. L., Corthesy-Theulaz  I. E.
ISSN
0019-9567 (Print)
Publication state
Published
Issued date
1999
Volume
67
Number
11
Pages
6206-6209
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't
Abstract
Mucosal immunization with Helicobacter heilmannii urease B or Helicobacter pylori urease, given nasally with cholera toxin, protects BALB/c mice against H. heilmannii infection and significantly reduces a preexisting infection. However, immunization aggravates gastric corpus atrophy. Our results underline the necessity of defining immunization regimens that do not enhance mucosal damage
Keywords
Animals/Atrophy/Bacterial Vaccines/immunology/Cholera Toxin/Gastric Mucosa/Pathology/Helicobacter/Helicobacter Infections/prevention & control/Immunity,Mucosal/Immunization/Mice/Mice,Inbred BALB C/Recombinant Proteins/Urease/Vaccines,Synthetic
OAI-PMH
oai:serval.unil.ch:BIB_E084BE5A1C8C
Pubmed
10531292
Web of science
000083343000095
Create date
29/01/2008 19:34
Last modification date
20/08/2019 17:04
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