Central control of glucose homeostasis: the brain--endocrine pancreas axis.

Détails

ID Serval
serval:BIB_E07505102FD3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Central control of glucose homeostasis: the brain--endocrine pancreas axis.
Périodique
Diabetes and Metabolism
Auteur(s)
Thorens B.
ISSN
1878-1780 (Electronic)
ISSN-L
1262-3636
Statut éditorial
Publié
Date de publication
2010
Volume
36
Numéro
Suppl 3
Pages
S45-S49
Langue
anglais
Résumé
A large body of data gathered over the last decades has delineated the neuronal pathways that link the central nervous system with the autonomic innervation of the endocrine pancreas, which controls alpha- and beta-cell secretion activity and mass. These are important regulatory functions that are certainly keys for preserving the capacity of the endocrine pancreas to control glucose homeostasis over a lifetime. Identifying the cells involved in controlling the autonomic innervation of the endocrine pancreas, in response to nutrient, hormonal and environmental cues and how these cues are detected to activate neuronal activity are important goals of current research. Elucidation of these questions may possibly lead to new means for preserving or restoring defects in insulin and glucagon secretion associated with type 2 diabetes.
Mots-clé
Animals, Autonomic Nervous System/physiology, Brain Stem/metabolism, Glucagon/metabolism, Glucose/metabolism, Homeostasis, Insulin/metabolism, Insulin-Secreting Cells/metabolism, Mice
Pubmed
Web of science
Création de la notice
09/05/2011 7:24
Dernière modification de la notice
20/08/2019 16:04
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