Tacrolimus ointment 0.03% for treatment of refractory childhood phlyctenular keratoconjunctivitis.
Details
Serval ID
serval:BIB_E0370F66D380
Type
Article: article from journal or magazin.
Publication sub-type
Minutes: analyse of a published work.
Collection
Publications
Institution
Title
Tacrolimus ointment 0.03% for treatment of refractory childhood phlyctenular keratoconjunctivitis.
Journal
Cornea
ISSN
1536-4798 (Electronic)
ISSN-L
0277-3740
Publication state
Published
Issued date
08/2012
Peer-reviewed
Oui
Volume
31
Number
8
Pages
950-952
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
To report 2 cases of refractory phlyctenular keratoconjunctivitis treated with topical tacrolimus 0.03% ointment (Protopic).
Two white children, aged 5 years and 6 years, respectively, presented with refractory phlyctenular keratoconjunctivitis in 1 eye (left). Both were using corticosteroids and oral erythromycin at presentation with no relief. Examination revealed the presence of catarrhal corneal infiltrates and neovascularization associated with corneal thinning. Topical tacrolimus was added to topical steroids and oral erythromycin twice daily.
Topical tacrolimus 0.03% ointment was applied into the lower fornix twice a day. In both the patients, improvement in symptoms and signs started within a week of therapy. After 3 weeks of treatment, both patients showed complete resolution of corneal infiltrates and neovascularization. Tacrolimus was successfully tapered in both the patients. There were no side effects.
Topical tacrolimus 0.03% ointment may be considered in treating severe refractory phlyctenular conjunctivitis.
Two white children, aged 5 years and 6 years, respectively, presented with refractory phlyctenular keratoconjunctivitis in 1 eye (left). Both were using corticosteroids and oral erythromycin at presentation with no relief. Examination revealed the presence of catarrhal corneal infiltrates and neovascularization associated with corneal thinning. Topical tacrolimus was added to topical steroids and oral erythromycin twice daily.
Topical tacrolimus 0.03% ointment was applied into the lower fornix twice a day. In both the patients, improvement in symptoms and signs started within a week of therapy. After 3 weeks of treatment, both patients showed complete resolution of corneal infiltrates and neovascularization. Tacrolimus was successfully tapered in both the patients. There were no side effects.
Topical tacrolimus 0.03% ointment may be considered in treating severe refractory phlyctenular conjunctivitis.
Keywords
Child, Child, Preschool, Cornea/pathology, Corneal Neovascularization/drug therapy, Female, Humans, Immunosuppressive Agents/administration & dosage, Keratoconjunctivitis/drug therapy, Ointments, Tacrolimus/administration & dosage
Pubmed
Web of science
Create date
01/10/2019 14:40
Last modification date
06/10/2019 6:26
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