Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?
Details
Request a copy Under indefinite embargo.UNIL restricted access
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_E030390F3794
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?
Journal
Movement disorders
ISSN
1531-8257 (Electronic)
ISSN-L
0885-3185
Publication state
Published
Issued date
04/2021
Peer-reviewed
Oui
Volume
36
Number
4
Pages
857-861
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Several lines of research point to a key role of low oxygen supply (hypoxia) in Parkinson's disease pathogenesis. Although severe hypoxia is detrimental for the brain, physiological adaptations to mild hypoxia are neuroprotective. Herein we discuss, how neuroprotective effects can be induced by hypoxia conditioning and how related approaches have the potential to be harnessed as therapeutic strategies in Parkinson's disease. © 2021 International Parkinson and Movement Disorder Society.
Keywords
Adaptation, Physiological, Humans, Hypoxia, Parkinson Disease/therapy, conditioning, hypoxia, mitochondria, neurodegeneration, α-synuclein
Pubmed
Web of science
Create date
09/03/2021 13:29
Last modification date
27/09/2022 5:39
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