Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.
Details
Serval ID
serval:BIB_DFBD7A674664
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.
Journal
Infection and Immunity
ISSN
0019-9567 (Print)
ISSN-L
0019-9567
Publication state
Published
Issued date
2003
Volume
71
Number
5
Pages
2924-2926
Language
english
Abstract
The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.
Keywords
Animals, Antigens, Protozoan, Base Sequence, Cysteine Endopeptidases/immunology, Humans, Interferon-gamma/biosynthesis, Interleukin-2/biosynthesis, Interleukin-4/biosynthesis, Leishmania guyanensis/immunology, Leishmaniasis, Cutaneous/immunology, Molecular Sequence Data, Protozoan Proteins/immunology, Protozoan Vaccines/immunology, Th1 Cells/immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:06
Last modification date
20/08/2019 17:04
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