Article: article from journal or magazin.
Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.
Infection and Immunity
The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.
Animals, Antigens, Protozoan, Base Sequence, Cysteine Endopeptidases/immunology, Humans, Interferon-gamma/biosynthesis, Interleukin-2/biosynthesis, Interleukin-4/biosynthesis, Leishmania guyanensis/immunology, Leishmaniasis, Cutaneous/immunology, Molecular Sequence Data, Protozoan Proteins/immunology, Protozoan Vaccines/immunology, Th1 Cells/immunology
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