Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions.

Details

Serval ID
serval:BIB_DF36B5556A3A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions.
Journal
Current Opinion in Biotechnology
Author(s)
Michalik L., Wahli W.
ISSN
0958-1669[print], 0958-1669[linking]
Publication state
Published
Issued date
12/1999
Volume
10
Number
6
Pages
564-570
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
The peroxisome proliferator-activated receptors (PPARs) are fatty acid and eicosanoid inducible nuclear receptors, which occur in three different isotypes. Upon activator binding, they modulate the expression of various target genes implicated in several important physiological pathways. During the past few years, the identification of both PPAR ligands, natural and synthetic, and PPAR targets and their associated functions has been one of the most important achievements in the field. It underscores the potential therapeutic application of PPAR-specific compounds on the one side, and the crucial biological roles of endogenous PPAR ligands on the other.
Keywords
Animals, Ligands, Protein Binding, Protein Isoforms/chemistry, Protein Isoforms/metabolism, Receptors, Cytoplasmic and Nuclear/chemistry, Receptors, Cytoplasmic and Nuclear/metabolism, Transcription Factors/chemistry, Transcription Factors/metabolism
Pubmed
Web of science
Create date
24/01/2008 15:44
Last modification date
20/08/2019 16:03
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