Calmodulin kinase IV: expression and function during rat brain development.

Details

Serval ID
serval:BIB_DEC5DB143B98
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Calmodulin kinase IV: expression and function during rat brain development.
Journal
Biochimica et Biophysica Acta. Molecular Cell Research
Author(s)
Krebs J., Honegger P.
ISSN
0167-4889
ISSN-L
1879-2596
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
1313
Number
3
Pages
217-222
Language
english
Abstract
The expression of calmodulin kinase IV (CaMKIV) can be induced by the thyroid hormone T3 in a time- and concentration-dependent manner at a very early stage of brain differentiation using a fetal rat telencephalon primary cell culture system which can grow and differentiate under chemically defined conditions (Krebs et al. (1996) J. Biol. Chem. 271, 11055-11058). After the induction of CaMKIV by T3 we examined the influence of prolonged absence of T3 from the culture medium on the expression of CaMKIV. We could demonstrate that after the T3-dependent induction of CaMKIV, omission of the hormone, even for 8 days, from the medium did not downregulate the expression of CaMKIV indicating that different regulatory mechanisms became important for the expression of the enzyme. We further showed that CaMKIV could be involved in the Ca(2+) -dependent expression of the immediate early gene c-fos, probably via phosphorylation of the transcription factor CREB. Convergence of signal transduction pathways on this transcription factor by using different protein kinases may explain the importance of CREB for the regulation of different cellular processes.
Keywords
Animals, Calcium-Calmodulin-Dependent Protein Kinases/analysis, Calcium-Calmodulin-Dependent Protein Kinases/biosynthesis, Cell Differentiation, Cells, Cultured, Enzyme Induction/drug effects, Enzyme Induction/physiology, Gene Expression Regulation, Developmental/drug effects, Gene Expression Regulation, Developmental/physiology, Genes, Immediate-Early/genetics, Genes, fos/genetics, RNA, Messenger/analysis, Rats, Telencephalon/chemistry, Telencephalon/cytology, Triiodothyronine/pharmacology, Triiodothyronine/physiology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 13:11
Last modification date
20/08/2019 16:03
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