Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones.

Details

Serval ID
serval:BIB_DE822C2B31C0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones.
Journal
Endocrinology
Author(s)
Jalouli M., Carlsson L., Améen C., Lindén D., Ljungberg A., Michalik L., Edén S., Wahli W., Oscarsson J.
ISSN
0013-7227[print], 0013-7227[linking]
Publication state
Published
Issued date
2003
Volume
144
Number
1
Pages
101-109
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Peroxisome proliferator-activated receptor (PPAR) alpha is a nuclear receptor that is mainly expressed in tissues with a high degree of fatty acid oxidation such as liver, heart, and skeletal muscle. Unsaturated fatty acids, their derivatives, and fibrates activate PPARalpha. Male rats are more responsive to fibrates than female rats. We therefore wanted to investigate if there is a sex difference in PPARalpha expression. Male rats had higher levels of hepatic PPARalpha mRNA and protein than female rats. Fasting increased hepatic PPARalpha mRNA levels to a similar degree in both sexes. Gonadectomy of male rats decreased PPARalpha mRNA expression to similar levels as in intact and gonadectomized female rats. Hypophysectomy increased hepatic PPARalpha mRNA and protein levels. The increase in PPARalpha mRNA after hypophysectomy was more pronounced in females than in males. GH treatment decreased PPARalpha mRNA and protein levels, but the sex-differentiated secretory pattern of GH does not determine the sex-differentiated expression of PPARalpha. The expression of PPARalpha mRNA in heart or soleus muscle was not influenced by gender, gonadectomy, hypophysectomy, or GH treatment. In summary, pituitary-dependent hormones specifically regulate hepatic PPARalpha expression. Sex hormones regulate the sex difference in hepatic PPARalpha levels, but not via the sexually dimorphic GH secretory pattern.
Keywords
Animals, Estradiol/pharmacology, Fasting, Female, Gene Expression/drug effects, Gonadal Steroid Hormones/physiology, Growth Hormone/pharmacology, Hypophysectomy, Liver/chemistry, Male, Muscle, Skeletal/chemistry, Myocardium/chemistry, Orchiectomy, Ovariectomy, Pituitary Hormones/physiology, RNA, Messenger/analysis, Rats, Rats, Sprague-Dawley, Receptors, Cytoplasmic and Nuclear/analysis, Receptors, Cytoplasmic and Nuclear/genetics, Sex Characteristics, Testosterone/pharmacology, Transcription Factors/analysis, Transcription Factors/genetics
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:43
Last modification date
20/08/2019 17:03
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