Increased circulating soluble CD14 is associated with high mortality in gram-negative septic shock

Details

Serval ID
serval:BIB_DE7898A1DE60
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased circulating soluble CD14 is associated with high mortality in gram-negative septic shock
Journal
Journal of Infectious Diseases
Author(s)
Landmann  R., Zimmerli  W., Sansano  S., Link  S., Hahn  A., Glauser  M. P., Calandra  T.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
03/1995
Volume
171
Number
3
Pages
639-44
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
The soluble glycoprotein sCD14 binds lipopolysaccharide, a complex that activates endothelial cells and that may be crucial in gram-negative sepsis. Therefore, serum sCD14 was analyzed in 54 patients with gram-negative septic shock and in 26 healthy controls. sCD14 was tested by ELISA and Western blotting. Patients had higher sCD14 concentrations than controls (median, 3.23 vs. 2.48 micrograms/mL, P = .002). Increased levels were associated with high mortality (median, 4.2 micrograms/mL in nonsurvivors vs. 2.8 micrograms/mL in survivors, P = .001). sCD14 was found in two isoforms (49 and 55 kDa) in monocyte cultures. In sera only one of either form was detectable. Controls had the 49-kDa form, and patients had either the 49- or 55-kDa form, but patients with high levels of sCD14 had only the 55-kDa form. Twenty-one (53%) of 39 with the 55-kDa form and 8 (57%) of 14 with the 49-kDa form died. Thus, the level of sCD14 but not its biochemical form had a prognostic value in patients with gram-negative septic shock.
Keywords
Adolescent Adult Aged Antigens, CD/*blood Antigens, CD14 Antigens, Differentiation, Myelomonocytic/*blood Blotting, Western Child Female Gram-Negative Bacterial Infections/*blood Humans Male Middle Aged Prognosis Shock, Septic/*blood
Pubmed
Web of science
Create date
25/01/2008 14:28
Last modification date
20/08/2019 17:03
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