Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation.
Details
Serval ID
serval:BIB_DE420BBAFD6B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Contralateral-eye study of surface refractive treatments: clinical and confocal microscopy evaluation.
Journal
Journal of cataract and refractive surgery
ISSN
1873-4502 (Electronic)
ISSN-L
0886-3350
Publication state
Published
Issued date
02/2014
Peer-reviewed
Oui
Volume
40
Number
2
Pages
224-231
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Publication Status: ppublish
Abstract
To compare the visual and refractive outcomes and the corneal structural changes in myopic patients after surface refractive treatments (ie, photorefractive keratectomy [PRK] with adjuvant mitomycin-C [MMC] and epithelial laser in situ keratomileusis [epi-LASIK]).
University of Crete, Heraklion, Crete, Greece.
Prospective comparative case series.
One eye of consecutive myopic patients was randomly assigned to PRK-MMC, and the fellow eye was treated with epi-LASIK. Visual and refractive outcomes and corneal confocal microscopy findings were evaluated. All patients were examined preoperatively and 1, 3, 6, 12, and 24 months postoperatively.
Twenty-six eyes (13 patients) were included. The mean follow-up was 2.47 years ± 0.35 (SD) (range 1.64 to 2.93 years). In the PRK-MMC group, the mean preoperative spherical equivalent refraction was -3.84 ± 1.59 diopters (D) (range -1.5 to -8.7 D) and -0.21 ± 0.44 D (range -0.5 to 1.0 D) at the last follow-up and in the epi-LASIK group, -3.91 ± 1.48 D (range -1.5 to -8.5 D) and -0.18 ± 0.36 (range +0.5 to -0.5 D), respectively. Qualitative analysis of the subepithelial nerve plexus, haze development, and keratocyte distribution were similar in the 2 groups. There was no statistically significant difference in endothelial cell density between the groups throughout the follow-up (P>.05).
Epithelial LASIK and PRK-MMC gave similar visual, refractive, and corneal structural outcomes in patients with myopia for up to 2 years postoperatively.
No author has a financial or proprietary interest in any material or method mentioned.
University of Crete, Heraklion, Crete, Greece.
Prospective comparative case series.
One eye of consecutive myopic patients was randomly assigned to PRK-MMC, and the fellow eye was treated with epi-LASIK. Visual and refractive outcomes and corneal confocal microscopy findings were evaluated. All patients were examined preoperatively and 1, 3, 6, 12, and 24 months postoperatively.
Twenty-six eyes (13 patients) were included. The mean follow-up was 2.47 years ± 0.35 (SD) (range 1.64 to 2.93 years). In the PRK-MMC group, the mean preoperative spherical equivalent refraction was -3.84 ± 1.59 diopters (D) (range -1.5 to -8.7 D) and -0.21 ± 0.44 D (range -0.5 to 1.0 D) at the last follow-up and in the epi-LASIK group, -3.91 ± 1.48 D (range -1.5 to -8.5 D) and -0.18 ± 0.36 (range +0.5 to -0.5 D), respectively. Qualitative analysis of the subepithelial nerve plexus, haze development, and keratocyte distribution were similar in the 2 groups. There was no statistically significant difference in endothelial cell density between the groups throughout the follow-up (P>.05).
Epithelial LASIK and PRK-MMC gave similar visual, refractive, and corneal structural outcomes in patients with myopia for up to 2 years postoperatively.
No author has a financial or proprietary interest in any material or method mentioned.
Keywords
Adult, Alkylating Agents/administration & dosage, Cell Count, Combined Modality Therapy, Cornea/innervation, Cornea/pathology, Corneal Keratocytes/pathology, Endothelium, Corneal/pathology, Female, Follow-Up Studies, Humans, Keratomileusis, Laser In Situ, Lasers, Excimer/therapeutic use, Male, Microscopy, Confocal, Mitomycin/administration & dosage, Myopia/pathology, Myopia/surgery, Ophthalmic Nerve/pathology, Photorefractive Keratectomy, Prospective Studies, Refraction, Ocular/physiology, Treatment Outcome, Visual Acuity/physiology, Young Adult
Pubmed
Web of science
Create date
01/10/2019 13:51
Last modification date
06/10/2019 6:26