CD4+ cytolytic T cell clone confers protection against murine malaria.

Details

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State: Public
Version: Final published version
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Serval ID
serval:BIB_DE29252575A5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Production externe
Title
CD4+ cytolytic T cell clone confers protection against murine malaria.
Journal
The Journal of experimental medicine
Author(s)
Tsuji M., Romero P., Nussenzweig R.S., Zavala F.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
01/11/1990
Peer-reviewed
Oui
Volume
172
Number
5
Pages
1353-1357
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
A CD4+ T cell clone (A1.6) was derived from spleen cells of mice immunized with irradiated sporozoites. This T cell clone recognizes an antigen that is shared by sporozoites and blood forms of Plasmodium berghei and differs from the circumsporozoite protein. Clone A1.6 displays cytotoxic activity, produces IFN-gamma and IL-2 in vitro, and recognizes the plasmodial antigen in the context of the class II I-Ed molecule. Passive transfer of this CD4+ clone into naive mice resulted in a high degree of protection against sporozoite challenge.
Keywords
Animals, Antibodies, Protozoan/immunology, Antigens, Protozoan/immunology, Apicomplexa/immunology, Apicomplexa/isolation & purification, CD4 Antigens/analysis, Clone Cells/immunology, Clone Cells/metabolism, Clone Cells/physiology, Female, Immunity, Cellular/immunology, Immunity, Cellular/physiology, Interferon-gamma/metabolism, Interleukin-2/metabolism, Malaria/immunology, Malaria/parasitology, Malaria/prevention & control, Mice, Mice, Inbred BALB C, Plasmodium berghei/immunology, Plasmodium berghei/isolation & purification, Spleen/cytology, Spleen/parasitology, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Cytotoxic/metabolism, T-Lymphocytes, Cytotoxic/physiology, T-Lymphocytes, Helper-Inducer/immunology, T-Lymphocytes, Helper-Inducer/metabolism, T-Lymphocytes, Helper-Inducer/physiology
DOI
10.1084/jem.172.5.1353
Pubmed
2146361
Web of science
A1990ED63400010
Open Access
Yes
Create date
28/01/2008 12:28
Last modification date
09/08/2024 13:20
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