Signals regulating hepatitis B surface antigen transcription.

Détails

ID Serval
serval:BIB_DE091B84F977
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Signals regulating hepatitis B surface antigen transcription.
Périodique
Nature
Auteur(s)
Cattaneo R., Will H., Hernandez N., Schaller H.
ISSN
0028-0836
Statut éditorial
Publié
Date de publication
09/1983
Peer-reviewed
Oui
Volume
305
Numéro
5932
Pages
336-338
Langue
anglais
Résumé
About 200 million people are chronic carriers of hepatitis B surface antigen (HBsAg), but since hepatitis B virus (HBV) cannot be propagated in vitro, HBsAg transcription has been studied only in cell lines containing HBV DNA integrated into chromosomes, and HBsAg-related mRNAs 2.0 to 2.5 kilobases (kb) long have been described. We have analysed the transcripts produced in an infected chimpanzee liver and in a rat cell line containing HBV DNA. In contrast to previous suppositions we report here that the major S gene transcript initiates close to the S gene, that is, within the 'pre-S' region and is processed/polyadenylated at a site situated within the core gene. The efficiency of processing/polyadenylation at this site varies between the chimpanzee liver and the rat cell line studied. The S gene promoter does not contain a TATA box but instead has a sequence homologous to that which positions the 5' ends of the major simian virus 40 (SV40) late transcript.
Mots-clé
Animals, Base Sequence, Gene Expression Regulation, Genes, Viral, Hepatitis B Surface Antigens, Liver, Operon, Pan troglodytes, Rats, Transcription, Genetic
Pubmed
Web of science
Création de la notice
21/01/2008 17:33
Dernière modification de la notice
20/08/2019 17:02
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