Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum.

Details

Serval ID
serval:BIB_DDAB35C4ACA0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum.
Journal
Alzheimer's & dementia
Author(s)
Bos I., Vos S., Verhey F., Scheltens P., Teunissen C., Engelborghs S., Sleegers K., Frisoni G., Blin O., Richardson J.C., Bordet R., Tsolaki M., Popp J., Peyratout G., Martinez-Lage P., Tainta M., Lleó A., Johannsen P., Freund-Levi Y., Frölich L., Vandenberghe R., Westwood S., Dobricic V., Barkhof F., Legido-Quigley C., Bertram L., Lovestone S., Streffer J., Andreasson U., Blennow K., Zetterberg H., Visser P.J.
ISSN
1552-5279 (Electronic)
ISSN-L
1552-5260
Publication state
Published
Issued date
05/2019
Peer-reviewed
Oui
Volume
15
Number
5
Pages
644-654
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We investigated relations between amyloid-β (Aβ) status, apolipoprotein E (APOE) ε4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau).
We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with Aβ status (Aβ- vs. Aβ+), clinical diagnosis APOE ε4 carriership, baseline cognition, and change in cognition.
Ng and T-tau distinguished between Aβ+ from Aβ- individuals in each clinical group, whereas NFL and YKL-40 were associated with Aβ+ in nondemented individuals only. APOE ε4 carriership did not influence NFL, Ng, and YKL-40 in Aβ+ individuals. NFL was the best predictor of cognitive decline in Aβ+ individuals across the cognitive spectrum.
Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker.
Keywords
Aged, Aged, 80 and over, Alzheimer Disease/cerebrospinal fluid, Alzheimer Disease/physiopathology, Amyloid beta-Peptides, Apolipoprotein E4/genetics, Biomarkers/cerebrospinal fluid, Cognitive Dysfunction/cerebrospinal fluid, Cognitive Dysfunction/physiopathology, Female, Humans, Neurofilament Proteins/cerebrospinal fluid, Neurogranin/cerebrospinal fluid, tau Proteins/cerebrospinal fluid, APOE, Alzheimer's disease, Amyloid-β, Cerebrospinal fluid, Cognition, Neurofilament light, Neurogranin, YKL-40
Pubmed
Web of science
Create date
28/03/2019 8:47
Last modification date
26/06/2020 5:21
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