Different Leishmania Species Drive Distinct Neutrophil Functions.

Détails

ID Serval
serval:BIB_DD8CCEBCF19D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Different Leishmania Species Drive Distinct Neutrophil Functions.
Périodique
Trends in Parasitology
Auteur(s)
Hurrell B.P., Regli I.B., Tacchini-Cottier F.
ISSN
1471-5007 (Electronic)
ISSN-L
1471-4922
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
32
Numéro
5
Pages
392-401
Langue
anglais
Résumé
Leishmaniases are vector-borne diseases of serious public health importance. During a sand fly blood meal, Leishmania parasites are deposited in the host dermis where neutrophils are rapidly recruited. Neutrophils are the first line of defense and can kill pathogens by an array of mechanisms. They can also form web-like structures called neutrophil extracellular traps (NETs) that can trap and/or kill microbes. The function of neutrophils in leishmaniasis was reported to be either beneficial by contributing to parasite killing or detrimental by impairing immune response development and control of parasite load. Here we review recent data showing that different Leishmania species elicit distinct neutrophil functions thereby influencing disease outcomes. Emerging evidence suggests that neutrophils should be considered important modulators of leishmaniasis.
Pubmed
Web of science
Création de la notice
15/03/2016 20:45
Dernière modification de la notice
20/08/2019 17:02
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