The effect of n-3 enriched nutrition therapy on post-operative cognitive dysfunction after cardiac surgery

Details

Serval ID
serval:BIB_DCDDFF641642
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
The effect of n-3 enriched nutrition therapy on post-operative cognitive dysfunction after cardiac surgery
Title of the conference
Annual meeting of the Swiss Society of Anaesthesiology and Resuscitation
Author(s)
Birkner-Binder D., Burkhart C.S., Monsch A.U., Grapow M., Eckstein F., Seeberger M.D., Filipovic M., Strebel S.P., Steiner L.A.
Address
Interlaken, Switzerland, October 29-31, 2009
ISBN
1424-7860
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
139
Series
Swiss Medical Weekly
Pages
7S-7S
Language
english
Notes
Meeting Abstract
Abstract
Background: Postoperative cognitive dysfunction (POCD) occurs frequently after cardiac surgery. Some data suggest that inflammation plays a key role in the development of POCD. N-3 fatty acids have been shown to have a beneficial effect on inflammation. We hypothesised that perioperative n-3 enriched nutrition therapy would reduce the incidence of POCD in this group of patients.
Methods: Randomized, double blind placebo controlled trial in patients aged 65 or older undergoing elective cardiac surgery with cardiopulmonary bypass. 2x 250 mL placebo (Ensure Plus™, Abbott Nutrition) or n-3 enriched nutrition therapy (ProSure™ Abbott Nutrition) were administered for ten days starting 5 days prior to surgery. Cognition was assessed preoperatively and 7 days after surgery with the Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB) [1].
Results: 16 patients were included. Mean age was 72 } 5.3 for placebo and 75 } 4.8 for ProSure™ respectively. CRP and IL-6 did not differ significantly between groups preoperatively and on postoperative days 1, 3, and 7. Preoperative CERAD total scores were 86 } 10 and 81 } 9 (p = n.s.) for Placebo and ProSure™, respectively. Postoperative scores were 88 } 12, and 77 } 19 (p = n.s.) The change in score was not different between the two groups (Placebo: +3 } 5; ProSure: -5 } 11).
Conclusion: In this very small sample no effect of preoperatively started n-3 enriched nutritional supplements on inflammation or cognitive functions were detected. However, there is a large likelihood of a type II error and more patients need to be included to assess possible beneficial effects of this intervention in elderly patients undergoing elective cardiac surgery. 1 Chandler MJ, et al. Neurology. 2005;65:102-6.
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Create date
19/11/2009 10:13
Last modification date
20/08/2019 16:01
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