Oculopalatal tremor: current concepts and new observations.

Détails

ID Serval
serval:BIB_DCB19C991AAD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Oculopalatal tremor: current concepts and new observations.
Périodique
Current Opinion In Neurology
Auteur(s)
Borruat F.X.
ISSN
1473-6551 (Electronic)
ISSN-L
1080-8248
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
26
Numéro
1
Pages
67-73
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
PURPOSE OF REVIEW: Oculopalatal tremor (OPT) is an acquired disorder resulting from the interruption of a specific brainstem circuitry, the dentato-rubro-olivary pathway or Guillain-Mollaret triangle. The recent literature on OPT and olivary hypertrophy was reviewed with specific interest regarding causes, diagnostic procedures, physiopathology and therapies.
RECENT FINDINGS: OPT is associated with inferior olivary hypertrophy, and recent findings have provided a better understanding of its intimate mechanisms. A dual-mechanism model, combining an oscillator (inferior olive) and a modulator/amplifier (cerebellum), best explains the development of OPT. Electrotonic coupling and specific Ca channels contribute to oscillations of inferior olivary nucleus neurons in OPT. Improvement of visual symptoms can be achieved with oral gabapentin or memantine.
SUMMARY: Both the neuronal circuitry and the physiopathology of OPT are now better understood. This opens up an era of specific therapy for this rare cause of disabling oscillopsia.
Pubmed
Web of science
Création de la notice
14/01/2013 11:42
Dernière modification de la notice
20/08/2019 16:01
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