Body composition and adiponectin serum concentrations in adult patients with cystic fibrosis.

Details

Serval ID
serval:BIB_DC6E1C15FBD6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Body composition and adiponectin serum concentrations in adult patients with cystic fibrosis.
Journal
Journal of Clinical Endocrinology and Metabolism
Author(s)
Moriconi N., Kraenzlin M., Müller B., Keller U., Nusbaumer C.P., Stöhr S., Tamm M., Puder J.J.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
91
Number
4
Pages
1586-1590
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
CONTEXT: Cystic fibrosis (CF) is a disease characterized by weight loss and chronic low-grade inflammation.
OBJECTIVE: The objective of the study was to assess changes in body composition and the serum concentrations of adiponectin, a marker of negative energy balance and insulin sensitivity, in adult patients with CF.
DESIGN: This was a cross-sectional study.
SETTING: The study was conducted at an outpatient clinic of the University Hospital of Basel, Switzerland.
PARTICIPANTS: Twenty-four stable adult CF patients and 24 healthy controls, matched for body mass index, age, sex, and hormonal therapy in women participated in the study.
MAIN OUTCOME MEASURES: Changes in body composition (assessed by dual x-ray absorptiometry) and serum adiponectin levels were measured.
RESULTS: Body mass index, percent fat mass (in percentage of body weight), and percent lean body mass were similar in patients and controls, whereas central fat accumulation was increased [trunk to extremity fat ratio 1.2 (0.99-1.51) vs. 0.99 (0.81-1.25), P = 0.01] in patients with CF, compared with controls. Decreased lean mass and increased highly sensitive C-reactive protein levels were independently associated with worse lung function in CF patients. Despite similar insulin resistance (homeostasis model assessment) and similar SHBG serum concentrations, the serum concentrations of adiponectin were higher in CF patients, compared with controls, independent of other confounders (P = 0.01).
CONCLUSIONS: Central fat accumulation is increased in patients with CF. It is postulated that the energy deficit-induced increase in serum adiponectin could explain the preservation of insulin sensitivity in these patients despite the increase in central fat and in highly sensitive C-reactive protein serum concentrations and could prevent a further deterioration of protein catabolism.
Keywords
Adiponectin/blood, Adult, Aged, Aged, 80 and over, Aging/metabolism, Anthropometry, Body Composition/physiology, Body Mass Index, Cystic Fibrosis/blood, Cystic Fibrosis/pathology, Female, Humans, Inflammation Mediators/physiology, Male, Middle Aged, Respiratory Function Tests, Sex Characteristics
Pubmed
Web of science
Open Access
Yes
Create date
15/02/2008 17:19
Last modification date
20/08/2019 16:01
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