Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts.

Détails

ID Serval
serval:BIB_DC69DC6196DF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Tannins from Syzygium guineense suppress Wnt signaling and proliferation of Wnt-dependent tumors through a direct effect on secreted Wnts.
Périodique
Cancer letters
Auteur(s)
Koval A., Pieme C.A., Queiroz E.F., Ragusa S., Ahmed K., Blagodatski A., Wolfender J.L., Petrova T.V., Katanaev V.L.
ISSN
1872-7980 (Electronic)
ISSN-L
0304-3835
Statut éditorial
Publié
Date de publication
28/10/2018
Peer-reviewed
Oui
Volume
435
Pages
110-120
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Triple-negative breast cancer (TNBC) and colon cancer (CC) are two stigmatic examples of poorly treatable tumors, whose progression critically depends upon hyperactivation of the Wnt signaling. Development of specific anti-Wnt inhibitors is required to develop drugs against these and other Wnt-dependent cancers. Natural products, especially plants, have been used for the treatment of various diseases from ancient times. We examined extracts from several indigenous Cameroonian herbs and tested their effects on proliferation and Wnt signaling in TNBC and CC cells. Extracts from "fruit rouge", Syzygium guineense Wall. (Myrtaceae), demonstrated a strong activity against these cancer cells, as well as CC organoids. We found TNBC cells to significantly upregulate expression of Wnt3a, and the effects of S. guineense extracts on TNBC cell proliferation correlated with inhibition of the Wnt3a-induced β-catenin stabilization and transcriptional response. HPLC analysis revealed that the active components belong to tannins. We found a direct destabilizing effect of S. guineense extract on Wnt3a and other Wnt proteins, identifying a novel mechanism of action of tannins on the Wnt signaling pathway and cancer cell proliferation. Being edible, this African plant may have an important cancer-preventive nutritional value.
Mots-clé
Cameroon, Cell Line, Tumor, Cell Proliferation/drug effects, Cell Proliferation/genetics, Cell Survival/drug effects, Cell Survival/genetics, Colonic Neoplasms/genetics, Colonic Neoplasms/metabolism, Colonic Neoplasms/pathology, Gene Expression Regulation, Neoplastic/drug effects, Humans, Plant Extracts/pharmacology, Syzygium/chemistry, Tannins/pharmacology, Triple Negative Breast Neoplasms/genetics, Triple Negative Breast Neoplasms/metabolism, Triple Negative Breast Neoplasms/pathology, Wnt Proteins/genetics, Wnt Proteins/metabolism, Wnt Signaling Pathway/drug effects, Wnt Signaling Pathway/genetics, Wnt3A Protein/genetics, Wnt3A Protein/metabolism, Colon cancer, Natural products, Polyphenols, Tannins, Triple-negative breast cancer, Wnt signaling
Pubmed
Web of science
Création de la notice
20/08/2018 13:27
Dernière modification de la notice
28/09/2019 5:08
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