Article: article from journal or magazin.
Mature dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15.
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
The CD8+ cell noncytotoxic anti-HIV response (CNAR) is associated with a long-term healthy clinical state in HIV-infected individuals. Over time CNAR is reduced concomitant with progression to disease. In studies to evaluate whether the interaction between CD8+ cells and dendritic cells (DCs) could increase CNAR, CD8+ cells from individuals who showed a decrease in this antiviral activity were cocultured with monocyte-derived dendritic cells matured with CD40 ligand. After coculture with these mature DCs, the CD8+ cells showed an increase in CNAR greater than that observed with CD8+ cells costimulated with CD3/CD28 antibodies. This antiviral response appeared to be mediated primarily by production of interleukin-15 (IL-15) by the mature DCs. Purified IL-15 also enhanced CNAR, whereas IL-12 showed no substantial effect. These studies provide another potential approach by which the immune system in HIV infection could be restored by cytokine therapy, particularly IL-15 administration.
Antigens, CD3/immunology, Antigens, CD8/immunology, CD8-Positive T-Lymphocytes/immunology, Cytokines/immunology, Cytokines/therapeutic use, Cytotoxicity, Immunologic/immunology, Dendritic Cells/immunology, Disease Progression, HIV Infections/immunology, Humans, Interleukin-15/immunology, Interleukin-15/therapeutic use, Reference Values
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