HBV or HCV coinfections and risk of myocardial infarction in HIV-infected individuals: the D:A:D Cohort Study.
Details
Serval ID
serval:BIB_DC158D701B7B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
HBV or HCV coinfections and risk of myocardial infarction in HIV-infected individuals: the D:A:D Cohort Study.
Journal
Antiviral Therapy
Working group(s)
Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group
Contributor(s)
Collins S., Dabis F., d'Arminio Monforte A., De Wit S., El-Sadr WM., Kirk O., Law M., Pizzuti D., Pradier C., Phillips A., Reiss P., Storfer SP., Weber R., Weller I., Lundgren JD., Worm SW., Friis-Møller N., Sabin CA., Sjøl A., Lundgren JD., Sawitz A., Rickenbach M., Pezzotti P., Krum E., Gras L., Balestre E., Sundström A., Poll B., Fontas E., Torres F., Marashi Pour S., Kjaer J., Hammer S., Neaton J., Sjøl A.
ISSN
2040-2058 (Electronic)
ISSN-L
1359-6535
Publication state
Published
Issued date
2010
Volume
15
Number
8
Pages
1077-1086
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
BACKGROUND: Data on a link between HCV or HBV infection and the development of cardiovascular disease among HIV-negative and HIV-positive individuals are conflicting. We sought to investigate the association between HBV or HCV infection and myocardial infarction in HIV-infected individuals.
METHODS: The prospective observational database of the D:A:D collaboration of 11 cohorts of HIV-infected individuals, including 212 clinics in Europe, the United States and Australia was used. Multivariate Poisson regression was used to assess the effect of HCV or HBV infection on the development of myocardial infarction after adjustment for potential confounders, including cardiovascular risk factors, diabetes mellitus and exposure to antiretroviral therapy.
RESULTS: Of 33,347 individuals, 517 developed a myocardial infarction over 157,912 person-years, with an event rate of 3.3 events/1,000 person-years (95% confidence interval [CI] 3.0-3.6). Event rates (95% CIs) per 1,000 person-years in those who were HCV-seronegative and HCV-seropositive were 3.3 (3.0-3.7) and 2.7 (2.2-3.3), respectively, and for those who were HBV-seronegative, had inactive infection or had active infection were 3.2 (2.8-3.5), 4.2 (3.1-5.2) and 2.8 (1.8-3.9), respectively. After adjustment, there was no association between HCV seropositivity (rate ratio 0.86 [95% CI 0.62-1.19]), inactive HBV infection (rate ratio 1.07 [95% CI 0.79-1.43]) or active HBV infection (rate ratio 0.78 [95% CI 0.52-1.15]) and the development of myocardial infarction.
CONCLUSIONS: We found no association between HBV or HCV coinfection and the development of myocardial infarction among HIV-infected individuals.
METHODS: The prospective observational database of the D:A:D collaboration of 11 cohorts of HIV-infected individuals, including 212 clinics in Europe, the United States and Australia was used. Multivariate Poisson regression was used to assess the effect of HCV or HBV infection on the development of myocardial infarction after adjustment for potential confounders, including cardiovascular risk factors, diabetes mellitus and exposure to antiretroviral therapy.
RESULTS: Of 33,347 individuals, 517 developed a myocardial infarction over 157,912 person-years, with an event rate of 3.3 events/1,000 person-years (95% confidence interval [CI] 3.0-3.6). Event rates (95% CIs) per 1,000 person-years in those who were HCV-seronegative and HCV-seropositive were 3.3 (3.0-3.7) and 2.7 (2.2-3.3), respectively, and for those who were HBV-seronegative, had inactive infection or had active infection were 3.2 (2.8-3.5), 4.2 (3.1-5.2) and 2.8 (1.8-3.9), respectively. After adjustment, there was no association between HCV seropositivity (rate ratio 0.86 [95% CI 0.62-1.19]), inactive HBV infection (rate ratio 1.07 [95% CI 0.79-1.43]) or active HBV infection (rate ratio 0.78 [95% CI 0.52-1.15]) and the development of myocardial infarction.
CONCLUSIONS: We found no association between HBV or HCV coinfection and the development of myocardial infarction among HIV-infected individuals.
Keywords
Adult, Australia/epidemiology, Cohort Studies, Europe/epidemiology, Female, HIV Infections/complications, Hepatitis B/complications, Hepatitis B/epidemiology, Hepatitis B Antibodies/blood, Hepatitis C/complications, Hepatitis C/epidemiology, Hepatitis C Antibodies/blood, Humans, Male, Multivariate Analysis, Myocardial Infarction/complications, Myocardial Infarction/epidemiology, Poisson Distribution, Prospective Studies, Regression Analysis, Risk Factors, Stroke/complications, Stroke/epidemiology, Substance Abuse, Intravenous/complications, Time Factors, United States/epidemiology
Pubmed
Create date
02/03/2011 17:45
Last modification date
20/08/2019 17:01
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