Comparative assessment of image quality for coronary CT angiography with iobitridol and two contrast agents with higher iodine concentrations: iopromide and iomeprol. A multicentre randomized double-blind trial.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_DBF61F3FE831
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparative assessment of image quality for coronary CT angiography with iobitridol and two contrast agents with higher iodine concentrations: iopromide and iomeprol. A multicentre randomized double-blind trial.
Journal
European radiology
Author(s)
Achenbach S., Paul J.F., Laurent F., Becker H.C., Rengo M., Caudron J., Leschka S., Vignaux O., Knobloch G., Benea G., Schlosser T., Andreu J., Cabeza B., Jacquier A., Souto M., Revel D., Qanadli S.D., Cademartiri F.
Working group(s)
X-ACT Study Group
ISSN
1432-1084 (Electronic)
ISSN-L
0938-7994
Publication state
Published
Issued date
02/2017
Peer-reviewed
Oui
Volume
27
Number
2
Pages
821-830
Language
english
Notes
Achenbach, Stephan Paul, Jan-Francois Laurent, Francois Becker, Hans-Christoph Rengo, Marco Caudron, Jerome Leschka, Sebastian Vignaux, Olivier Knobloch, Gesine Benea, Giorgio Schlosser, Thomas Andreu, Jordi Cabeza, Beatriz Jacquier, Alexis Souto, Miguel Revel, Didier Qanadli, Salah Dine Cademartiri, Filippo ENG 2016/06/09 06:00 Eur Radiol. 2016 Jun 7.
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
To demonstrate non-inferiority of iobitridol 350 for coronary CT angiography (CTA) compared to higher iodine content contrast media regarding rate of patients evaluable for the presence of coronary artery stenoses.
In this multicentre trial, 452 patients were randomized to receive iobitridol 350, iopromide 370 or iomeprol 400 and underwent coronary CTA using CT systems with 64-detector rows or more. Two core lab readers assessed 18 coronary segments per patient regarding image quality (score 0 = non diagnostic to 4 = excellent quality), vascular attenuation, signal and contrast to noise ratio (SNR, CNR). Patients were considered evaluable if no segment had a score of 0.
Per-patient, the rate of fully evaluable CT scans was 92.1, 95.4 and 94.6 % for iobitridol, iopromide and iomeprol, respectively. Non-inferiority of iobitridol over the best comparator was demonstrated with a 95 % CI of the difference of [-8.8 to 2.1], with a pre-specified non-inferiority margin of -10 %. Although average attenuation increased with higher iodine concentrations, average SNR and CNR did not differ between groups.
With current CT technology, iobitridol 350 mg iodine/ml is not inferior to contrast media with higher iodine concentrations in terms of image quality for coronary stenosis assessment.
• Iodine concentration is an important parameter for image quality in coronary CTA. • Contrast enhancement must be balanced against the amount of iodine injected. • Iobitridol 350 is non-inferior compared to CM with higher iodine concentrations. • Higher attenuation with higher iodine concentrations, but no SNR or CNR differences.

Keywords
Adult, Aged, Calcinosis/diagnostic imaging, Computed Tomography Angiography/methods, Contrast Media, Coronary Angiography/methods, Coronary Artery Disease/diagnostic imaging, Coronary Stenosis/diagnostic imaging, Double-Blind Method, Female, Humans, Iodine, Iohexol/analogs & derivatives, Iopamidol/analogs & derivatives, Male, Middle Aged, Multidetector Computed Tomography/methods, Tomography, X-Ray Computed/methods
Pubmed
Open Access
Yes
Create date
21/06/2016 8:59
Last modification date
20/08/2019 16:00
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