Article: article from journal or magazin.
Two-kidney, one clip and one-kidney, one clip hypertension in mice.
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
The mouse remains the animal of choice in transgenic experiments, creating a need for methods of evaluating the physiology of genetically modified animals. We have established and characterized two murine models of renovascular hypertension known as the two-kidney, one clip and one-kidney, one clip models. The appropriate size of the clip lumen needed to induce high blood pressure was determined to be 0.12 mm. Clips with a lumen of 0.11 mm induced a high percentage of renal infarction, and clips with a 0.13-mm opening did not produce hypertension. Four weeks after clipping, two-kidney, one clip hypertensive mice exhibited blood pressure approximately 20 mm Hg higher than their sham-operated controls. After a similar period, this increase reached almost 35 mm Hg in the one-kidney, one clip model. Depending on the model, mice develop either renin-dependent or renin-independent hypertension. Both models are characterized by the development of cardiovascular hypertrophy.
Animals, Base Sequence, Blood Pressure, Blotting, Northern, Cardiomegaly, Heart Rate, Hemodynamics, Hypertension, Renovascular, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Molecular Sequence Data, Polymerase Chain Reaction, RNA, Renin
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