Novel naphthoquinones from Conospermum incurvum

Détails

ID Serval
serval:BIB_DB0FF15E695B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Novel naphthoquinones from Conospermum incurvum
Périodique
Journal of Natural Products
Auteur(s)
Dai  J. R., Decosterd  L. A., Gustafson  K. R., Cardellina, J. H., 2nd , Gray  G. N., Boyd  M. R.
ISSN
0163-3864 (Print)
Statut éditorial
Publié
Date de publication
11/1994
Volume
57
Numéro
11
Pages
1511-6
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
During the reisolation of the trimeric naphthoquinone derivative conocurvone [1] from an extract of the Australian shrub Conospermum incurvum, six monomeric naphthoquinones were isolated. These include three novel 1,4-naphthoquinone derivatives: 3-methyl-14,15-dihydro-15-hydroxyteretifolione B [3], 3-methyl-14,15-dihydro-15-hydroxyteretifolione B methyl ether [4], and 2,3-dimethyl-6-hydroxy-7-methoxy-1,4-naphthoquinone [5]. In addition, the previously reported compounds 3-methylteretifolione B [6], 3-methylteretifolione B methyl ether [7], and 8-geranyl-2,7-dihydroxy-3-methyl-1,4-naphthoquinone [8] were isolated and identified. The structures of the novel 1,4-naphthoquinones were elucidated by spectral methods. While conocurvone [1] is a potent inhibitor of HIV-1-induced cell killing, all of the monomeric naphthoquinone derivatives were inactive against HIV-1.
Mots-clé
Antiviral Agents/*chemistry/isolation & purification/pharmacology Australia Cell Survival/drug effects HIV-1/*drug effects/pathogenicity Humans Magnetic Resonance Spectroscopy Molecular Structure Naphthoquinones/*chemistry/isolation & purification/pharmacology Plant Roots Plants/*chemistry
Pubmed
Web of science
Création de la notice
25/01/2008 11:51
Dernière modification de la notice
20/08/2019 17:00
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