Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF.

Details

Serval ID
serval:BIB_DAEB848928EF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF.
Journal
Pigment Cell and Melanoma Research
Author(s)
Anghel S.I., Correa-Rocha R., Correa-Rochal R., Budinska E., Boligan K.F., Boliganl K.F., Abraham S., Colombetti S., Fontao L., Mariotti A., Rimoldi D., Ghanem G.E., Fisher D.E., Lévy F., Delorenzi M., Piguet V.
ISSN
1755-148X (Electronic)
ISSN-L
1755-1471
Publication state
Published
Issued date
2012
Volume
25
Number
4
Pages
482-487
Language
english
Abstract
Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MM-derived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.
Keywords
Amino Acid Sequence, Animals, Cell Cycle, Cell Line, Tumor, Cell Proliferation, Down-Regulation/genetics, Gene Expression Regulation, Neoplastic, Humans, Melanoma/genetics, Melanoma/pathology, Mice, Microphthalmia-Associated Transcription Factor/genetics, Microphthalmia-Associated Transcription Factor/metabolism, Molecular Sequence Data, Neoplasm Proteins/chemistry, Neoplasm Proteins/metabolism, Protein Binding, SOXE Transcription Factors/metabolism, Skin Neoplasms/genetics, Skin Neoplasms/pathology, Tumor Suppressor Proteins/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2013 8:54
Last modification date
20/08/2019 16:00
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