Interrogating open issues in cancer precision medicine with patient-derived xenografts.

Details

Serval ID
serval:BIB_DAE66A3080A8
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Interrogating open issues in cancer precision medicine with patient-derived xenografts.
Journal
Nature reviews. Cancer
Author(s)
Byrne A.T., Alférez D.G., Amant F., Annibali D., Arribas J., Biankin A.V., Bruna A., Budinská E., Caldas C., Chang D.K., Clarke R.B., Clevers H., Coukos G., Dangles-Marie V., Eckhardt S.G., Gonzalez-Suarez E., Hermans E., Hidalgo M., Jarzabek M.A., de Jong S., Jonkers J., Kemper K., Lanfrancone L., Mælandsmo G.M., Marangoni E., Marine J.C., Medico E., Norum J.H., Palmer H.G., Peeper D.S., Pelicci P.G., Piris-Gimenez A., Roman-Roman S., Rueda O.M., Seoane J., Serra V., Soucek L., Vanhecke D., Villanueva A., Vinolo E., Bertotti A., Trusolino L.
ISSN
1474-1768 (Electronic)
ISSN-L
1474-175X
Publication state
Published
Issued date
04/2017
Peer-reviewed
Oui
Volume
17
Number
4
Pages
254-268
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective of EurOPDX, an international initiative devoted to PDX-based research.

Pubmed
Web of science
Create date
30/01/2017 19:19
Last modification date
20/08/2019 16:00
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