Circadian plasticity evolves through regulatory changes in a neuropeptide gene.

Details

Serval ID
serval:BIB_DADDDDFC79F5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Circadian plasticity evolves through regulatory changes in a neuropeptide gene.
Journal
Nature
Author(s)
Shahandeh M.P., Abuin L., Lescuyer De Decker L., Cergneux J., Koch R., Nagoshi E., Benton R.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Publication state
Published
Issued date
16/10/2024
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Many organisms, including cosmopolitan drosophilids, show circadian plasticity, varying their activity with changing dawn-dusk intervals <sup>1</sup> . How this behaviour evolves is unclear. Here we compare Drosophila melanogaster with Drosophila sechellia, an equatorial, ecological specialist that experiences minimal photoperiod variation, to investigate the mechanistic basis of circadian plasticity evolution <sup>2</sup> . D. sechellia has lost the ability to delay its evening activity peak time under long photoperiods. Screening of circadian mutants in D. melanogaster/D. sechellia hybrids identifies a contribution of the neuropeptide pigment-dispersing factor (Pdf) to this loss. Pdf exhibits species-specific temporal expression, due in part to cis-regulatory divergence. RNA interference and rescue experiments in D. melanogaster using species-specific Pdf regulatory sequences demonstrate that modulation of this neuropeptide's expression affects the degree of behavioural plasticity. The Pdf regulatory region exhibits signals of selection in D. sechellia and across populations of D. melanogaster from different latitudes. We provide evidence that plasticity confers a selective advantage for D. melanogaster at elevated latitude, whereas D. sechellia probably suffers fitness costs through reduced copulation success outside its range. Our findings highlight this neuropeptide gene as a hotspot locus for circadian plasticity evolution that might have contributed to both D. melanogaster's global distribution and D. sechellia's specialization.
Pubmed
Web of science
Open Access
Yes
Create date
25/10/2024 13:06
Last modification date
31/10/2024 13:45
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