Hemoglobin Levels and the Risk of Malaria in Papua New Guinean Infants: A Nested Cohort Study.

Details

Serval ID
serval:BIB_DACFA28FDAB9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hemoglobin Levels and the Risk of Malaria in Papua New Guinean Infants: A Nested Cohort Study.
Journal
The American journal of tropical medicine and hygiene
Author(s)
Lombardo P., Vaucher P., Rarau P., Mueller I., Favrat B., Senn N.
ISSN
1476-1645 (Electronic)
ISSN-L
0002-9637
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
97
Number
6
Pages
1770-1776
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Studies are available that assess the risk of malaria in accordance to the body's iron store and the systematic iron supplementation of preschool children. However, only a few studies evaluated the temporal association between hemoglobin and malaria and their results are opposing. A total of 1,650 3-month-old Papua New Guinean infants were enrolled in this study and followed-up for 12 months. The risk of malaria was assessed in all children every 3 months and with each episode of fever. The incidence of clinical malaria between 3 and 15 months of age was 249 cases per 1,000 infants per year. After adjustment for potential confounding factors, a decrease of 1 g/dL of hemoglobin was associated with a nonsignificant increase of 11% for risk of malaria infection (hazard ratio, 1.11, 95% confidence interval; CI, 0.99-1.25, javax.xml.bind.JAXBElement@9ecc9e6 = 0.076). Only children with severe anemia (hemoglobin < 8.0 g/dL) at baseline were at higher risk of malaria infection (hazard ratio, 1.72, 95% CI, 1.08-2.76, javax.xml.bind.JAXBElement@5fb60f18 = 0.023) during the follow-up year compared with the control group (Hemoglobin > 10.0 g/dL). This association was not statistically significant if only clinical malaria episodes were taken into account (hazard ratio, 1.42, 95% CI, 0.77-2.61, javax.xml.bind.JAXBElement@4573b140 = 0.26). Our study suggests that infants with lower hemoglobin levels are not protected against malaria infection. Further research that examines the risk of malaria in relation to both hemoglobin and iron store levels would be important to better understand this complex interaction.

Keywords
Anemia, Iron-Deficiency/blood, Anemia, Iron-Deficiency/drug therapy, Anemia, Iron-Deficiency/epidemiology, Cohort Studies, Dietary Supplements, Female, Hemoglobins/analysis, Humans, Incidence, Infant, Iron, Dietary/administration & dosage, Malaria/blood, Malaria/drug therapy, Malaria/epidemiology, Male, Papua New Guinea/epidemiology, Proportional Hazards Models, Risk Factors, Sensitivity and Specificity
Pubmed
Web of science
Open Access
Yes
Create date
11/10/2017 13:02
Last modification date
20/08/2019 15:59
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