The effect of a period of intensive exercise on the isoform test to detect growth hormone doping in sports.
Details
Serval ID
serval:BIB_DACC6653F554
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The effect of a period of intensive exercise on the isoform test to detect growth hormone doping in sports.
Journal
Growth Hormone and Igf Research : Official Journal of the Growth Hormone Research Society and the International Igf Research Society
ISSN
1532-2238 (Electronic)
ISSN-L
1096-6374
Publication state
Published
Issued date
2013
Volume
23
Number
4
Pages
105-108
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
OBJECTIVE: The major objective of this study was to investigate the effects of several days of intense exercise on growth hormone (hGH) testing using the World Anti-Doping Agencies hGH isoform differential immunoassays. Additionally the effects of circadian variation and exercise type on the isoform ratios were also investigated.
STUDY DESIGN: 15 male athletes performed a simulated nine day cycling stage race. Blood samples were collected twice daily over a period of 15days (stage race+three days before and after). hGH isoforms were analysed by the official WADA immunoassays (CMZ Assay GmbH).
RESULTS: All measured isoform ratios were far below the WADA decision limits for an adverse analytical finding. Changes in the isoform ratios could not be clearly connected to circadian variation, exercise duration or intensity.
CONCLUSIONS: The present study demonstrates that the hGH isoform ratios are not significantly affected by exercise or circadian variation. We demonstrated that heavy, long term exercise does not interfere with the decision limits for an adverse analytical finding.
STUDY DESIGN: 15 male athletes performed a simulated nine day cycling stage race. Blood samples were collected twice daily over a period of 15days (stage race+three days before and after). hGH isoforms were analysed by the official WADA immunoassays (CMZ Assay GmbH).
RESULTS: All measured isoform ratios were far below the WADA decision limits for an adverse analytical finding. Changes in the isoform ratios could not be clearly connected to circadian variation, exercise duration or intensity.
CONCLUSIONS: The present study demonstrates that the hGH isoform ratios are not significantly affected by exercise or circadian variation. We demonstrated that heavy, long term exercise does not interfere with the decision limits for an adverse analytical finding.
Keywords
Doping, hGH, Isoforms, Sport, Exercise
Pubmed
Web of science
Create date
26/07/2013 16:11
Last modification date
20/08/2019 15:59
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