[(18)F]Fluoroethyltyrosine- positron emission tomography-guided radiotherapy for high-grade glioma.

Détails

ID Serval
serval:BIB_DAB3D5C1B5F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
[(18)F]Fluoroethyltyrosine- positron emission tomography-guided radiotherapy for high-grade glioma.
Périodique
Radiation Oncology
Auteur(s)
Weber D.C., Zilli T., Buchegger F., Casanova N., Haller G., Rouzaud M., Nouet P., Dipasquale G., Ratib O., Zaidi H., Vees H., Miralbell R.
ISSN
1748-717X[electronic]
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
3
Numéro
44
Pages
[11 p.]
Langue
anglais
Résumé
BACKGROUND: To compare morphological gross tumor volumes (GTVs), defined as pre- and postoperative gadolinium enhancement on T1-weighted magnetic resonance imaging to biological tumor volumes (BTVs), defined by the uptake of (18)F fluoroethyltyrosine (FET) for the radiotherapy planning of high-grade glioma, using a dedicated positron emission tomography (PET)-CT scanner equipped with three triangulation lasers for patient positioning. METHODS: Nineteen patients with malignant glioma were included into a prospective protocol using FET PET-CT for radiotherapy planning. To be eligible, patients had to present with residual disease after surgery. Planning was performed using the clinical target volume (CTV = GTV union or logical sum BTV) and planning target volume (PTV = CTV + 20 mm). First, the interrater reliability for BTV delineation was assessed among three observers. Second, the BTV and GTV were quantified and compared. Finally, the geometrical relationships between GTV and BTV were assessed. RESULTS: Interrater agreement for BTV delineation was excellent (intraclass correlation coefficient 0.9). Although, BTVs and GTVs were not significantly different (p = 0.9), CTVs (mean 57.8 +/- 30.4 cm(3)) were significantly larger than BTVs (mean 42.1 +/- 24.4 cm(3); p < 0.01) or GTVs (mean 38.7 +/- 25.7 cm(3); p < 0.01). In 13 (68%) and 6 (32%) of 19 patients, FET uptake extended >or= 10 and 20 mm from the margin of the gadolinium enhancement. CONCLUSION: Using FET, the interrater reliability had excellent agreement for BTV delineation. With FET PET-CT planning, the size and geometrical location of GTVs and BTVs differed in a majority of patients.
Mots-clé
Adult, Aged, Brain Neoplasms, Female, Fluorine Radioisotopes, Glioma, Humans, Male, Middle Aged, Observer Variation, Positron-Emission Tomography, Radiopharmaceuticals, Radiotherapy Planning, Computer-Assisted, Tyrosine
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/03/2009 10:27
Dernière modification de la notice
09/05/2019 2:05
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