Frequency and chronology of extraintestinal manifestations in the Swiss Inflammatory Bowel Disease Cohort
Details
Serval ID
serval:BIB_DA9B362B5E83
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Frequency and chronology of extraintestinal manifestations in the Swiss Inflammatory Bowel Disease Cohort
Title of the conference
DDW 2012, Digestive Disease Week
Address
San Diego, California, United-States, May 20-22, 2012
ISBN
0016-5085
ISSN-L
0021-9355
Publication state
Published
Issued date
2012
Volume
142
Series
Gastroenterology
Pages
S669
Language
english
Abstract
Background: Data on the frequency of extraintestinal manifestations (EIM) in inflammatory
bowel disease (IBD) is scarce, especially the one evaluating the time of occurrence of the
EIM relative to IBD diagnosis. Aim: To assess the type and frequency of EIM in IBD patients
and to evaluate when EIMs occur relative to IBD diagnosis. Methods: Analysis of data from
the Swiss Inflammatory Bowel Disease Cohort (SIBDCS) which collects data on a large
sample of IBD patients from hospitals and private practices across Switzerland starting in
2005. While parametric data are shown as mean ± SD, non-parametric data are presented
as median and interquartile range (IQR). Results: A total of 1143 patients were analyzed
(572 (50%) female, mean age 42.1 ± 14.4 years): 629 (55%) with Crohn's disease (CD),
501 (44%) with ulcerative colitis (UC), and 13 (1%) with indeterminate colitis (IC). Of
1143 patients, 374 (32.7%) presented with EIM (65% with CD, 33% with UC, 2% with
IC). Of those patients suffering from EIMs, 37.4% presented with one, 41.7% with two,
12.4% with three, 5.3% with four, and 3.2% with five EIM during their lifetime. The
IBD patients initially presented with the following EIMs: peripheral arthritis (PA) 63.4%,
ankylosing spondylitis (AS) 8.1%, primary sclerosing cholangitis (PSC) 6.0%, uveitis 5.7%,
oral aphthosis 5.7%, erythema nodosum (EN) 5.0%, pyoderma gangrenosum 1.8%, psoriasis
0.7%. While 92.9% of EIM occurred once IBD diagnosis was established (median 72 months,
IQR 9-147 months, p < 0.001), 7.1% of EIMs preceded IBD diagnosis (median time 28
months before IBD diagnosis, IQR 7-60 months). Over a course of a lifetime, IBD patients
presented with the following EIM (total exceeds 100 due to potential presence of multiple
EIM): peripheral arthritis 69.3%, oral aphthosis 23%, ankylosing spondylitis 19.4%, uveitis
15.5%, erythema nodosum 14.5%, PSC 7.8%, pyoderma gangrenosum 6%, psoriasis 2.8%.
Conclusion: EIMs frequently occur in a lifetime of IBD patients. The vast majority of patients
present with EIMs once IBD diagnosis has been established. IBD patients most often present
with peripheral arthritis, ankylosing spondylitis and PSC as their first EIM. However, peripheral
arthritis, oral aphthosis, and ankylosing spondylitis are the most common EIMs in
a lifetime of IBD patients.
bowel disease (IBD) is scarce, especially the one evaluating the time of occurrence of the
EIM relative to IBD diagnosis. Aim: To assess the type and frequency of EIM in IBD patients
and to evaluate when EIMs occur relative to IBD diagnosis. Methods: Analysis of data from
the Swiss Inflammatory Bowel Disease Cohort (SIBDCS) which collects data on a large
sample of IBD patients from hospitals and private practices across Switzerland starting in
2005. While parametric data are shown as mean ± SD, non-parametric data are presented
as median and interquartile range (IQR). Results: A total of 1143 patients were analyzed
(572 (50%) female, mean age 42.1 ± 14.4 years): 629 (55%) with Crohn's disease (CD),
501 (44%) with ulcerative colitis (UC), and 13 (1%) with indeterminate colitis (IC). Of
1143 patients, 374 (32.7%) presented with EIM (65% with CD, 33% with UC, 2% with
IC). Of those patients suffering from EIMs, 37.4% presented with one, 41.7% with two,
12.4% with three, 5.3% with four, and 3.2% with five EIM during their lifetime. The
IBD patients initially presented with the following EIMs: peripheral arthritis (PA) 63.4%,
ankylosing spondylitis (AS) 8.1%, primary sclerosing cholangitis (PSC) 6.0%, uveitis 5.7%,
oral aphthosis 5.7%, erythema nodosum (EN) 5.0%, pyoderma gangrenosum 1.8%, psoriasis
0.7%. While 92.9% of EIM occurred once IBD diagnosis was established (median 72 months,
IQR 9-147 months, p < 0.001), 7.1% of EIMs preceded IBD diagnosis (median time 28
months before IBD diagnosis, IQR 7-60 months). Over a course of a lifetime, IBD patients
presented with the following EIM (total exceeds 100 due to potential presence of multiple
EIM): peripheral arthritis 69.3%, oral aphthosis 23%, ankylosing spondylitis 19.4%, uveitis
15.5%, erythema nodosum 14.5%, PSC 7.8%, pyoderma gangrenosum 6%, psoriasis 2.8%.
Conclusion: EIMs frequently occur in a lifetime of IBD patients. The vast majority of patients
present with EIMs once IBD diagnosis has been established. IBD patients most often present
with peripheral arthritis, ankylosing spondylitis and PSC as their first EIM. However, peripheral
arthritis, oral aphthosis, and ankylosing spondylitis are the most common EIMs in
a lifetime of IBD patients.
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14/02/2013 18:17
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