Organic acids in the second morning urine in a healthy Swiss paediatric population.

Détails

ID Serval
serval:BIB_DA904D2B4D32
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Organic acids in the second morning urine in a healthy Swiss paediatric population.
Périodique
Clinical Chemistry and Laboratory Medicine
Auteur(s)
Boulat O., Gradwohl M., Matos V., Guignard J.P., Bachmann C.
ISSN
1434-6621
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
41
Numéro
12
Pages
1642-1658
Langue
anglais
Résumé
Organic acid analysis is used for the early detection/ exclusion and for the follow-up of inherited disorders of amino acid and organic acid metabolism. Urinary organic acid concentrations in 417 healthy Caucasian children (1 day to 17 years of age) were determined after liquid solid extraction, as their trimethylsilyl derivatives, by gas chromatography and mass spectrometry. Concentrations of most of the organic acids adjusted for creatinine tend to decrease with age. No differences were found between gender except for the Krebs cycle intermediates in the older age groups. In neonates, the immaturity of the neonatal kidney led to a much larger variation of organic acid levels when related to creatinine. The low number of subjects (n = 36-52) per age class resulted in large 95% confidence intervals of the percentiles used for decision. This must be taken into account when using the data for exclusion or diagnosis of disorders.
Mots-clé
Adolescent, Carboxylic Acids/urine, Child, Child, Preschool, European Continental Ancestry Group, Female, Gas Chromatography-Mass Spectrometry/methods, Humans, Infant, Infant, Newborn, Male, Organic Chemicals/urine, Switzerland
Pubmed
Web of science
Création de la notice
05/02/2008 11:24
Dernière modification de la notice
03/03/2018 21:55
Données d'usage