Immune responses to Helicobacter pylori infection.

Details

Serval ID
serval:BIB_DA5DE749B3F7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immune responses to Helicobacter pylori infection.
Journal
World Journal of Gastroenterology
Author(s)
Moyat M., Velin D.
ISSN
2219-2840 (Electronic)
ISSN-L
1007-9327
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
20
Number
19
Pages
5583-5593
Language
english
Notes
Publication types: REVIEW Publication Status: ppublish
Abstract
Helicobacter pylori (H. pylori) infection is one of the most common infections in human beings worldwide. H. pylori express lipopolysaccharides and flagellin that do not activate efficiently Toll-like receptors and express dedicated effectors, such as γ-glutamyl transpeptidase, vacuolating cytotoxin (vacA), arginase, that actively induce tolerogenic signals. In this perspective, H. pylori can be considered as a commensal bacteria belonging to the stomach microbiota. However, when present in the stomach, H. pylori reduce the overall diversity of the gastric microbiota and promote gastric inflammation by inducing Nod1-dependent pro-inflammatory program and by activating neutrophils through the production of a neutrophil activating protein. The maintenance of a chronic inflammation in the gastric mucosa and the direct action of virulence factors (vacA and cytotoxin-associated gene A) confer pro-carcinogenic activities to H. pylori. Hence, H. pylori cannot be considered as symbiotic bacteria but rather as part of the pathobiont. The development of a H. pylori vaccine will bring health benefits for individuals infected with antibiotic resistant H. pylori strains and population of underdeveloped countries.
Pubmed
Web of science
Open Access
Yes
Create date
20/06/2014 17:28
Last modification date
20/08/2019 15:59
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