Association between Inflammatory and Obesity Markers in a Swiss Population-Based Sample (CoLaus Study).

Détails

ID Serval
serval:BIB_DA50485EACAD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association between Inflammatory and Obesity Markers in a Swiss Population-Based Sample (CoLaus Study).
Périodique
Obesity Facts
Auteur(s)
Marques-Vidal P., Bochud M., Bastardot F., Lüscher T., Ferrero F., Gaspoz J.M., Paccaud F., Urwyler A., von Känel R., Hock C., Waeber G., Preisig M., Vollenweider P.
ISSN
1662-4033 (Electronic)
ISSN-L
1662-4025
Statut éditorial
Publié
Date de publication
10/2012
Volume
5
Numéro
5
Pages
734-744
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Objective: To assess the associations between obesity markers (BMI, waist circumference and %body fat) and inflammatory markers (interleukin-1β (IL-1β); interleukin-6 (IL-6); tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP)). Methods: Population sample of 2,884 men and 3,201 women aged 35-75 years. Associations were assessed using ridge regression adjusting for age, leisure-time physical activity, and smoking. Results: No differences were found in IL-1β levels between participants with increased obesity markers and healthy counterparts; multivariate regression showed %body fat to be negatively associated with IL-1β. Participants with high %body fat or abdominal obesity had higher IL-6 levels, but no independent association between IL-6 levels and obesity markers was found on multivariate regression. Participants with abdominal obesity had higher TNF-α levels, and positive associations were found between TNF-α levels and waist circumference in men and between TNF-α levels and BMI in women. Obese participants had higher hs-CRP levels, and these differences persisted after multivariate adjustment; similarly, positive associations were found between hs-CRP levels and all obesity markers studied. Conclusion: Obesity markers are differentially associated with cytokine levels. %Body fat is negatively associated with IL-1β; BMI (in women) and waist circumference (in men) are associated with TNF-α; all obesity markers are positively associated with hs-CRP. Copyright © 2012 S. Karger GmbH, Freiburg.
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/11/2012 15:59
Dernière modification de la notice
09/05/2019 2:04
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