Effects of a nonpressor dose of neuropeptide Y on cardiac output, regional blood flow distribution and plasma renin, vasopressin and catecholamine levels.

Détails

ID Serval
serval:BIB_DA3C8B44EDA7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of a nonpressor dose of neuropeptide Y on cardiac output, regional blood flow distribution and plasma renin, vasopressin and catecholamine levels.
Périodique
Journal of Pharmacology and Experimental Therapeutics
Auteur(s)
Aubert J.F., Burnier M., Waeber B., Nussberger J., Dipette D.J., Burris J.F., Brunner H.R.
ISSN
0022-3565
Statut éditorial
Publié
Date de publication
1988
Peer-reviewed
Oui
Volume
244
Numéro
3
Pages
1109-1115
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Neuropeptide Y (NPY) is a peptide with vasoconstrictor properties known to be present in the central nervous system as well as in sympathetic nerve endings and the adrenal medulla. The purposes of this study were to investigate in normotensive conscious rats the effects of nonpressor doses of NPY on cardiac output and regional blood flow distribution (using radiolabeled microspheres) as well as on plasma renin activity, plasma catecholamine and vasopressin levels. NPY (0.1 microgram/min) infused i.v. for 30 min modified neither blood pressure nor heart rate. Cardiac index was at comparable levels in NPY- as in vehicle-treated rats (17.7 +/- 1.6, n = 8, vs. 21.3 +/- 0.9 ml/min/100 g, n = 8, mean +/- S.E.M.). There was no significant difference in regional blood flow distribution between the two groups of rats, except for the large intestine (0.42 +/- 0.06 vs. 0.71 +/- 0.1 ml/min/g in NPY- and vehicle-treated rats, respectively, P less than .05). Basal plasma renin activity and catecholamine levels were not modified by NPY whereas plasma vasopressin levels were lower (P less than .05) in rats given NPY (0.76 +/- 0.3 pg/ml, n = 8) than in those having received the vehicle (2.2 +/- 0.4 pg/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Animals, Arginine Vasopressin, Blood Pressure, Cardiac Output, Catecholamines, Male, Neuropeptide Y, Phentolamine, Rats, Rats, Inbred Strains, Regional Blood Flow, Renin
Pubmed
Web of science
Création de la notice
25/01/2008 13:56
Dernière modification de la notice
03/03/2018 21:54
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