Reduction of Respiratory Motion During PET/CT by Pulsatile-Flow Ventilation: A First Clinical Evaluation.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_DA38095A6DCE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reduction of Respiratory Motion During PET/CT by Pulsatile-Flow Ventilation: A First Clinical Evaluation.
Périodique
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Auteur(s)
Prior J.O., Péguret N., Pomoni A., Pappon M., Zeverino M., Belmondo B., Lovis A., Ozsahin M., Vienne M., Bourhis J.
ISSN
1535-5667 (Electronic)
ISSN-L
0161-5505
Statut éditorial
Publié
Date de publication
03/2016
Peer-reviewed
Oui
Volume
57
Numéro
3
Pages
416-419
Langue
anglais
Notes
Publication types: Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Respiratory motion negatively affects PET/CT image quality and quantitation. A novel Pulsatile-Flow Ventilation (PFV) system reducing respiratory motion was applied in spontaneously breathing patients to induce sustained apnea during PET/CT.
Four patients (aged 65 ± 14 y) underwent PET/CT for pulmonary nodule staging (mean, 11 ± 7 mm; range, 5-18 mm) at 63 ± 3 min after (18)F-FDG injection and then at 47 ± 7 min afterward, during PFV-induced apnea (with imaging lasting ≥8.5 min). Anterior-posterior thoracic amplitude, SUVmax, and SUVpeak (SUVmean in a 1-cm-diameter sphere) were compared.
PFV PET/CT reduced thoracic amplitude (80%), increased mean lesion SUVmax (29%) and SUVpeak (11%), decreased lung background SUVpeak (25%), improved lesion detectability, and increased SUVpeak lesion-to-background ratio (54%). On linear regressions, SUVmax and SUVpeak significantly improved (by 35% and 23%, respectively; P ≤ 0.02).
PFV-induced apnea reduces thoracic organ motion and increases lesion SUV, detectability, and delineation, thus potentially affecting patient management by improving diagnosis, prognostication, monitoring, and external-radiation therapy planning.

Mots-clé
Aged, Apnea/diagnostic imaging, Apnea/physiopathology, Female, Fluorodeoxyglucose F18, Humans, Image Processing, Computer-Assisted, Lung/diagnostic imaging, Lung Neoplasms/diagnostic imaging, Lung Neoplasms/physiopathology, Male, Middle Aged, Motion, Positron-Emission Tomography, Predictive Value of Tests, Radiopharmaceuticals, Respiration, Artificial, Respiratory Mechanics, Solitary Pulmonary Nodule/diagnostic imaging
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/01/2016 15:44
Dernière modification de la notice
20/08/2019 15:59
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