Acute respiratory syndrome after inhalation of waterproofing sprays: a posteriori exposure-response assessment in 102 cases

Détails

ID Serval
serval:BIB_DA30242B8C85
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Acute respiratory syndrome after inhalation of waterproofing sprays: a posteriori exposure-response assessment in 102 cases
Périodique
Journal of Occupational and Environmental Hygiene
Auteur(s)
Vernez David, Bruzzi Raffaella, Kupferschmidt Hugo, De Batz Alice, Droz Pierre-Olivier, Lazor Romain
ISSN
1545-9624
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
3
Numéro
5
Pages
250-261
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't
Résumé
Waterproofing agents are widely used to protect leather and textiles in both domestic and occupational activities. An outbreak of acute respiratory syndrome following exposure to waterproofing sprays occurred during the winter 2002-2003 in Switzerland. About 180 cases were reported by the Swiss Toxicological Information Centre between October 2002 and March 2003, whereas fewer than 10 cases per year had been recorded previously. The reported cases involved three brands of sprays containing a common waterproofing mixture, that had undergone a formulation change in the months preceding the outbreak. A retrospective analysis was undertaken in collaboration with the Swiss Toxicological Information Centre and the Swiss Registries for Interstitial and Orphan Lung Diseases to clarify the circumstances and possible causes of the observed health effects. Individual exposure data were generated with questionnaires and experimental emission measurements. The collected data was used to conduct numeric simulation for 102 cases of exposure. A classical two-zone model was used to assess the aerosol dispersion in the near- and far-field during spraying. The resulting assessed dose and exposure levels obtained were spread on large scales, of several orders of magnitude. No dose-response relationship was found between exposure indicators and health effects indicators (perceived severity and clinical indicators). Weak relationships were found between unspecific inflammatory response indicators (leukocytes, C-reactive protein) and the maximal exposure concentration. The results obtained disclose a high interindividual response variability and suggest that some indirect mechanism(s) predominates in the respiratory disease occurrence. Furthermore, no threshold could be found to define a safe level of exposure. These findings suggest that the improvement of environmental exposure conditions during spraying alone does not constitute a sufficient measure to prevent future outbreaks of waterproofing spray toxicity. More efficient preventive measures are needed prior to the marketing and distribution of new waterproofing agents.
Mots-clé
Aerosols/toxicity Air Pollutants/*toxicity C-Reactive Protein Computer Simulation Dyspnea/chemically induced Fluorocarbon Polymers/*toxicity Humans Inhalation Exposure/*adverse effects Leukocyte Count Models, Theoretical Questionnaires Respiration Respiratory Tract Diseases/*chemically induced/epidemiology Textiles
Pubmed
Web of science
Création de la notice
10/02/2009 13:14
Dernière modification de la notice
03/03/2018 21:54
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