Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses.

Details

Serval ID
serval:BIB_DA2E5C1D1F4D
Type
Article: article from journal or magazin.
Collection
Publications
Title
Airflow decline after myeloablative allogeneic hematopoietic cell transplantation: the role of community respiratory viruses.
Journal
The Journal of infectious diseases
Author(s)
Erard V., Chien J.W., Kim H.W., Nichols W.G., Flowers M.E., Martin P.J., Corey L., Boeckh M.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
15/06/2006
Peer-reviewed
Oui
Volume
193
Number
12
Pages
1619-1625
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
We conducted a 12-year retrospective study to determine the effects that the community respiratory-virus species and the localization of respiratory-tract virus infection have on severe airflow decline, a serious and fatal complication occurring after hematopoietic cell transplantation (HCT). Of 132 HCT recipients with respiratory-tract virus infection during the initial 100 days after HCT, 50 (38%) developed airflow decline < or =1 year after HCT. Lower-respiratory-tract infection with parainfluenza (odds ratio [OR], 17.9 [95% confidence interval {CI}, 2.0-160]; P=.01) and respiratory syncytial virus (OR, 3.6 [95% CI, 1.0-13]; P=.05) independently increased the risk of development of airflow decline < or =1 year after HCT. The airflow decline was immediately detectable after infection and was strongest for lower-respiratory-tract infection with parainfluenza virus; it stabilized during the months after the respiratory-tract virus infection, but, at < or =1 year after HCT, the initial lung function was not restored. Thus, community respiratory virus-associated airflow decline seems to be specific to viral species and infection localization.
Keywords
Adult, Community-Acquired Infections/physiopathology, Community-Acquired Infections/virology, Cytomegalovirus Infections/physiopathology, Female, Hematopoietic Stem Cell Transplantation, Humans, Male, Middle Aged, Paramyxoviridae Infections/physiopathology, Pneumonia, Viral/physiopathology, Pulmonary Ventilation, Respiratory Syncytial Virus Infections/physiopathology, Respiratory Tract Infections/physiopathology, Respiratory Tract Infections/virology, Retrospective Studies, Risk Factors, Transplantation, Homologous
Pubmed
Web of science
Open Access
Yes
Create date
02/02/2010 16:33
Last modification date
12/02/2022 13:38
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