Article: article from journal or magazin.
A monoclonal antibody against altered LFA-1 induces proliferation and lymphokine release of cloned T cells.
European Journal of Immunology
A murine monoclonal antibody (I-17, IgM) has the following functional effects on murine long-term T cell clones: inhibition of cell-mediated lysis, induction of proliferation, release of lymphokines and change of the cell morphology. The determinant detected by I-17 is expressed on long-term T lines but not on thymocytes, lymph node cells and spleen cells. I-17 precipitated proteins with apparent molecular mass of 220 kDa, 170 kDa, 150 kDa and 100 kDa. Biochemical studies indicate that the determinant recognized by I-17 is tunicamycin sensitive and that I-17 binds to the alpha chain of the lymphocyte function-associated antigen (LFA-1).
Animals, Antibodies, Monoclonal/biosynthesis, Antibodies, Monoclonal/immunology, Antigens, Surface/analysis, Antigens, Surface/immunology, Cell Adhesion, Chemical Precipitation, Clone Cells, Concanavalin A/pharmacology, Cytotoxicity, Immunologic, Epitopes/analysis, Female, Lymphocyte Activation, Lymphocyte Function-Associated Antigen-1, Lymphokines/secretion, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Protein Conformation, T-Lymphocytes/immunology, T-Lymphocytes, Cytotoxic/ultrastructure, Tunicamycin/pharmacology
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