High Evening Cortisol Level Is Associated With Low TBS and Increased Prevalent Vertebral Fractures: OsteoLaus Study.

Détails

ID Serval
serval:BIB_DA0158609A94
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
High Evening Cortisol Level Is Associated With Low TBS and Increased Prevalent Vertebral Fractures: OsteoLaus Study.
Périodique
The Journal of clinical endocrinology and metabolism
Auteur(s)
Gonzalez Rodriguez E., Lamy O., Stoll D., Metzger M., Preisig M., Kuehner C., Vollenweider P., Marques-Vidal P., Waeber G., Aubry-Rozier B., Hans D.
ISSN
1945-7197 (Electronic)
ISSN-L
0021-972X
Statut éditorial
Publié
Date de publication
01/07/2017
Peer-reviewed
Oui
Volume
102
Numéro
7
Pages
2628-2636
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Increased evening cortisol levels have been implicated in bone mineral density (BMD) loss. The effect on bone microarchitecture and fracture risk has never been studied.
To study the relationship between salivary cortisol circadian rhythm and (1) trabecular bone score (TBS) and (2) fracture prevalence.
Cross-sectional study including 608 women >50 years old (mean = 65.5) from the OsteoLaus cohort. Data included the FRAX© questionnaire, BMD, TBS and vertebral fracture (VFx) assessment by dual X-ray absorptiometry, and measures of salivary cortisol (awakening, 30 minutes thereafter, 11 am, and 8 pm).
In the multivariate model, participants in the highest tertile of 8 pm salivary cortisol (sc-8 pm) (mean = 5.7 ± 2.5 nmol/L) vs lowest tertile (1.7 ± 0.4 nmol/L) had lower TBS values (1.27 vs 1.29; P = 0.02), more prevalent VFx grades 2 and 3 (odds ratio = 5.34; P = 0.012), low-trauma fractures (odds ratio = 1.80; P = 0.036), and major osteoporotic fractures (odds ratio = 1.96; P = 0.042), without difference in lumbar spine BMD (0.91 vs 0.92 g/cm2; P = 0.431). VFx prevalence was associated with sc-8 pm and TBS independently of each other and of other risk factors. The cut-point for sc-8 pm correlating with the presence of >1 VFx was 3.62 nmol/L (sensitivity 0.74, specificity 0.66).
High sc-8 pm is associated with low TBS and an increased prevalence of radiologic VFx independently of other risk factors. Measurement of sc-8 pm may add relevant information in the assessment of fracture risk.

Mots-clé
Absorptiometry, Photon, Aged, Aged, 80 and over, Aging/physiology, Bone Density, Cancellous Bone/metabolism, Circadian Rhythm, Cross-Sectional Studies, Female, Humans, Hydrocortisone/blood, Hydrocortisone/secretion, Incidence, Middle Aged, Multivariate Analysis, Osteoporotic Fractures/blood, Osteoporotic Fractures/diagnostic imaging, Osteoporotic Fractures/epidemiology, Prognosis, ROC Curve, Reference Values, Risk Assessment, Salivary Glands/secretion, Spinal Fractures/blood, Spinal Fractures/epidemiology, Switzerland
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/12/2017 16:52
Dernière modification de la notice
09/05/2019 2:02
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